{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:31:24Z","timestamp":1783603884055,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T00:00:00Z","timestamp":1699142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K10311"],"award-info":[{"award-number":["JP17K10311"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K07504"],"award-info":[{"award-number":["JP21K07504"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to examine potential cognitive impairments in patients with alcohol use disorder (AUD), and explore the factors affecting them. We recruited 97 inpatients with AUD, showing superficially normal cognitive function (mini\u2010mental state examination score \u226524) for this study. We assessed cognitive function after a 4\u2010week post\u2010abstinence period using the Brief Assessment of Cognition in Schizophrenia\u2010Japanese version (BACS\u2010J). Relationships between BACS\u2010J subcategory\/composite raw scores and <jats:italic>Z<\/jats:italic>\u2010scores (deviation from standard data in healthy Japanese) and background factors such as age, sex, education, smoking status, mini\u2010mental state examination score, body mass index, systolic blood pressure, severity of depression, alcohol consumption, and laboratory findings were analyzed. Multiple regression analysis showed that the age (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and total bilirubin level (<jats:italic>p<\/jats:italic>\u2009=\u20090.014) were worsening factors for the BACS\u2010J composite raw score, whereas education (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) was a protective factor. An inverse correlation was apparent between the age and the composite <jats:italic>Z<\/jats:italic>\u2010score of the BACS\u2010J (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.431, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Receiver operating characteristic (ROC) analysis identified 53\u2009years as the cutoff age for predicting more than \u22122SD cognitive decline from the normal standard, with a high negative predictive value (95%). Patients with AUD aged \u226553\u2009years showed more pronounced impairments in verbal memory, working memory, verbal fluency, and attention than those younger than 53\u2009years (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). These findings clearly demonstrate accelerated age\u2010related cognitive decline in patients with AUD, especially those aged \u226553\u2009years, suggesting the necessity of early intervention in patients with AUD to prevent progressive cognitive impairment and preserve their quality of life.<\/jats:p>","DOI":"10.1002\/npr2.12395","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T05:07:29Z","timestamp":1699247249000},"page":"587-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Age\u2010related cognitive decline is accelerated in alcohol use disorder"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2032-3873","authenticated-orcid":false,"given":"Kazuhiro","family":"Kurihara","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Graduate School of Medicine University of the Ryukyus  Okinawa 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