{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:16:27Z","timestamp":1781108187349,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T00:00:00Z","timestamp":1705190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K06998"],"award-info":[{"award-number":["23K06998"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This systematic review and frequentist network meta\u2010analysis used random\u2010effects models is conducted to determine whether there are differences in the efficacy, acceptability, tolerability, and safety profiles of brexpiprazole (BRE) and aripiprazole (ARI) for Japanese with major depressive disorder (MDD) who were inadequately responsive to antidepressants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Outcome measures were scores on the Montgomery \u00c5sberg Depression Rating Scale (primary), the Clinical Global Impression severity scale, and social functioning scale; the non\u2010response rate; the non\u2010remission rate; all\u2010cause discontinuation; discontinuation due to adverse events (DAE); at least one adverse event (1AE); serious adverse event, akathisia; tremor; weight gain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A literature search identified three double\u2010blind, randomized, placebo\u2010controlled trials. These comprised one BRE study (with a 1\u2009mg\/day [BRE1] and a 2\u2009mg\/day [BRE2]) and two ARI studies (with a 3\u2009mg\/day arm and a flexible\u2010dose arm[within the dosage range approved in Japan]) (<jats:italic>n<\/jats:italic>\u2009=\u20091736). Both BRE and ARI demonstrated better efficacy than the placebo. BRE but not ARI had a higher DAE than the placebo. ARI but not BRE had a higher 1AE than the placebo. BRE and ARI had a higher risk of akathisia and weight gain than the placebo. There were no significant differences between BRE and ARI for any of the outcomes. Although BRE1 had good efficacy, it carried risk of weight gain. Although BRE2 also had efficacy, it carried risks of DAE, akathisia, and weight gain. However, the risk of akathisia in BRE2 was reduced by an initial dose of 0.5\u2009mg\/day rather than 1.0\u2009mg\/day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall BRE showed similar utility to ARI and a good risk\u2013benefit balance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12414","type":"journal-article","created":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T22:29:48Z","timestamp":1705271388000},"page":"165-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of brexpiprazole, aripiprazole, and placebo for Japanese major depressive disorder: A systematic review and network meta\u2010analysis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9237-2236","authenticated-orcid":false,"given":"Taro","family":"Kishi","sequence":"first","affiliation":[{"name":"Department of Psychiatry Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, School of Medicine St. Marianna University  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-7272","authenticated-orcid":false,"given":"Masaki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kansai Medical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakao","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13651501.2017.1306082"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881115581093"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0706743716659417"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.20.251405"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.21120"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-020-05472-5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S176676"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyz040"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.13615"},{"key":"e_1_2_11_11_1","unstructured":"FDA.https:\/\/www.fda.gov\/."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02203-y"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12091362"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-019-00750-8"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2791"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14m09689"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"e_1_2_11_18_1","unstructured":"HigginsJ ThomasJ ChandlerJ CumpstonM LiT PageM et\u00a0al.Cochrane handbook for systematic reviews of interventions version 6.2.2021www.trainingcochrane.org\/handbook"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_2_11_20_1","volume-title":"Manual for the ECDEU assessment battery","author":"Guy W","year":"1970"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00788510"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(97)00420-3"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_11_24_1","unstructured":"R\u00fcckerG SchwarzerG KrahnU K\u00f6nigJ.netmeta: Network Meta\u2010Analysis using Frequentist Methods (R package version 0.9\u20135).2017. 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