{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:17:31Z","timestamp":1778800651029,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K10141"],"award-info":[{"award-number":["22K10141"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Burning mouth syndrome (BMS) is characterized by burning sensations in the oral region without corresponding abnormalities and is often accompanied by uncomfortable sensations. Herein, we present cases of BMS in which the remaining uncomfortable sensations improved with perospirone augmentation with clonazepam. Case 1: A 61\u2010year\u2010old man complained of a burning pain in his tongue, a sensation of dryness and discomfort as if his tongue was sticking to a palatal plate. With the diagnosis of BMS, psychopharmacotherapy was initiated with amitriptyline. At the dose of amitriptyline 50\u2009mg, the pain lessened but uncomfortable sensations persisted. Further attempts to alleviate symptoms by combining aripiprazole with amitriptyline, aripiprazole with mirtazapine, or aripiprazole with clonazepam were limited; however, nearly all symptoms were relieved by a combination of perospirone 8.0\u2009mg with clonazepam 1.5\u2009mg. Case 2: A 51\u2010year\u2010old woman complained of a burning sensation along with oral dryness and crumb\u2010like feeling on her tongue. She was diagnosed with BMS and began treatment with amitriptyline. Her burning sensation improved at the dose of 25\u2009mg, but uncomfortable sensations persisted. Augmentation of amitriptyline with aripiprazole, aripiprazole either with valproate, mirtazapine, or clonazepam failed to produce a significant improvement. However, a regimen of perospirone 6.0\u2009mg and clonazepam 1.5\u2009mg relieved the crumb\u2010like sensation and pain and culminated in a stabilized condition. The reported cases suggested that multiple approaches targeting the dopaminergic circuit in basal ganglia involving the serotoninergic and GABA systems, through the administration of perospirone with clonazepam is an effective adjunctive treatment for the remaining uncomfortable sensations in patients with BMS.<\/jats:p>","DOI":"10.1002\/npr2.12425","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T05:39:46Z","timestamp":1710826786000},"page":"464-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effective perospirone augmentation with clonazepam for treatment\u2010resistant burning mouth syndrome: A case report"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0767-197X","authenticated-orcid":false,"given":"Motoko","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9509-4959","authenticated-orcid":false,"given":"Chihiro","family":"Takao","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9344-8828","authenticated-orcid":false,"given":"Chizuko","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7722-9741","authenticated-orcid":false,"given":"Gayatri","family":"Nayanar","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4933-7899","authenticated-orcid":false,"given":"Risa","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2089-6389","authenticated-orcid":false,"given":"Yasuyuki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-4603","authenticated-orcid":false,"given":"Trang Thi Huyen","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"},{"name":"Department of Basic Dental Sciences, Faculty of Odonto\u2010stomatology University of Medicine and Pharmacy  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0690-6271","authenticated-orcid":false,"given":"Takahiko","family":"Nagamine","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"},{"name":"Department of Psychiatric Internal Medicine Sunlight Brain Research Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9498-3014","authenticated-orcid":false,"given":"Akira","family":"Toyofuku","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13030-016-0068-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13030\u2010016\u20100071\u20107"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S167527"},{"issue":"4","key":"e_1_2_9_5_1","first-page":"814","article-title":"Low\u2010dose aripiprazole augmentation in amitriptyline\u2010resistant burning mouth syndrome: results from two 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