{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:02:31Z","timestamp":1756461751880,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vortioxetine, known for its efficacy in treating depression through its effects on various neurotransmitters, has not been previously reported to induce syndrome of inappropriate secretion of antidiuretic hormone (SIADH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>This case report describes a 74\u2010year\u2010old man with major depressive disorder who developed SIADH 1\u2009week after starting treatment with vortioxetine. SIADH is characterized by symptoms such as headache, nausea, disorientation, and seizures, stemming from hyponatremia (123\u2009mEq\/L), without dehydration or edema. Vortioxetine was discontinued, and an alternative drug, mianserin, was initiated. The patient was restricted from drinking water due to hyponatremia. The serum Na concentration improved over time to within the normal range by the second week after admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first case report of vortioxetine\u2010induced SIADH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12438","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T12:44:49Z","timestamp":1712580289000},"page":"479-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vortioxetine\u2010induced syndrome of inappropriate secretion of antidiuretic hormone: A case report"],"prefix":"10.1002","volume":"44","author":[{"given":"Taro","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Psychiatry School of Medicine, Dokkyo Medical University  Shimotsuga Tochigi 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