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Findings from different studies highlighted the beneficial and detrimental effects of serum uric acid on the development and progression of NDs. Therefore, this mini\u2010review aims to discuss the beneficial and detrimental effects of uric on NDs. The neuroprotective effect of uric acid is mainly related to the antioxidant effect of uric acid which alleviates oxidative stress\u2010induced neurodegeneration in AD and PD. However, long\u2010term effect of hyperuricemia prompts for the development and progression of cognitive impairment. Hyperuricemia is associated with cognitive impairment and dementia, and gout increases dementia risk. In addition, hyperuricemia can cause cerebral vascular injury which is a risk factor for vascular dementia and cognitive impairment. Taken together, the relationship between uric acid and NDs risk remains conflicting. Hence, preclinical and clinical studies are indicated in this regard.<\/jats:p>","DOI":"10.1002\/npr2.12445","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T05:50:18Z","timestamp":1722318618000},"page":"639-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Role of uric acid in neurodegenerative diseases, focusing on Alzheimer and Parkinson disease: A new perspective"],"prefix":"10.1002","volume":"44","author":[{"given":"Mohammed","family":"Alrouji","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences Shaqra University  Shaqra Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayder M.","family":"Al\u2010kuraishy","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Medicine, College of Medicine Mustansiriyah University  Baghdad 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