{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:43:50Z","timestamp":1747151030521,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Yokukansan is one of the most frequently used herbal medicines that can improve the behavioral and psychological symptoms of dementia. In this exploratory study, we investigated whether yokukansan affects the steady\u2010state blood concentrations of donepezil, risperidone, and the major metabolites of both drugs in a real\u2010world clinical setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A non\u2010randomized, open\u2010label, single\u2010arm study examining drug\u2013drug interactions was conducted. Fifteen dementia patients taking donepezil for at least 4\u2009weeks and eight schizophrenia patients taking risperidone for at least 2\u2009weeks were orally administered 2.5\u2009g of yokukansan three times a day before or between meals, and blood samples were collected before and 8\u2009weeks after starting co\u2010treatment with yokukansan. Plasma concentrations of donepezil, risperidone, and each metabolite were measured using high\u2010performance liquid chromatography\u2013tandem mass spectrometry and compared before and after the 8\u2010week administration of yokukansan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The plasma concentrations of donepezil and its metabolites (6\u2010<jats:italic>O<\/jats:italic>\u2010desmethyl\u2010donepezil, 5\u2010<jats:italic>O<\/jats:italic>\u2010desmethyl\u2010donepezil, and donepezil\u2010<jats:italic>N<\/jats:italic>\u2010oxide), risperidone, and its metabolite paliperidone did not differ before and after the 8\u2010week treatment with yokukansan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of this study show that the concomitant use of yokukansan may have little clinical impact on the steady\u2010state blood levels of donepezil and risperidone in patients with dementia or schizophrenia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.12459","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T05:52:25Z","timestamp":1720504345000},"page":"614-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of concomitant use of yokukansan on steady\u2010state blood concentrations of donepezil and risperidone in real\u2010world clinical practice"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6266-1347","authenticated-orcid":false,"given":"Junji","family":"Saruwatari","sequence":"first","affiliation":[{"name":"Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Therapeutics, Graduate 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