{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T20:49:15Z","timestamp":1791751755111,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010traumatic stress disorder (PTSD) is a mental health disorder resulting from exposure to traumatic events, manifesting in various debilitating symptoms. Despite available treatments, many individuals experience inadequate response or significant side effects. Previous reviews suggest promising outcomes with MDMA\u2010assisted psychotherapy (MDMA\u2010AT), but limitations prompt the need for a comprehensive evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We searched various online databases and registries such as MEDLINE (via PubMed), Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      to retrieve RCTs that fit our inclusion criteria. We performed meta\u2010analyses using Review Manager by applying a random\u2010effects model. Dichotomous and continuous outcomes were pooled as risk ratios (RR) and standard mean difference (SMD), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine studies with a total of 297 participants with PTSD were included in our meta\u2010analysis. The control group consisted of inactive doses of MDMA (25\u201340\u2009mg) or placebo. Our meta\u2010analysis showed that MDMA\u2010AT led to a significant reduction in the Clinician\u2010Administered PTSD Scale for DSM\u20105 (CAPS\u20105) severity scores as compared to the control group (SMD \u22121.10, 95% CI: \u22121.62 to \u22120.59). More patients in the MDMA\u2010AT group exhibited significant response (RR 1.59, 95% CI: 1.22, 2.08) and remission (RR 2.32, 95% CI: 1.47 to 3.66) as compared to patients in the control group. There was no significant difference regarding the incidence of \u22651 treatment\u2010emergent adverse events (TEAE), \u22651 severe TEAE, and suicidal ideation between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MDMA\u2010AT demonstrates significant efficacy in improving PTSD symptoms, enhancing both response and remission rates in individuals with chronic, treatment\u2010resistant PTSD, while maintaining a favorable safety profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.12485","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T04:54:37Z","timestamp":1728449677000},"page":"672-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["<scp>MDMA<\/scp>\n                    \u2010assisted psychotherapy for the treatment of\n                    <scp>PTSD<\/scp>\n                    : A systematic review and meta\u2010analysis of randomized controlled trials (\n                    <scp>RCTs<\/scp>\n                    )"],"prefix":"10.1002","volume":"44","author":[{"given":"Ghada","family":"Shahrour","sequence":"first","affiliation":[{"name":"Department of Community and Mental Health Nursing, Faculty of Nursing Jordan University of Science and Technology  Irbid Jordan"},{"name":"College of Nursing RAK Medical and Health Sciences University  Ras Al\u2010Khaimah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kainat","family":"Sohail","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Jinnah Sindh Medical University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa","family":"Elrais","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Tripoli  Tripoli 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