{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:45:05Z","timestamp":1791254705646,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP16dk0307060"],"award-info":[{"award-number":["JP16dk0307060"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19dk0307083"],"award-info":[{"award-number":["JP19dk0307083"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22dk0307112"],"award-info":[{"award-number":["JP22dk0307112"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009048","name":"Japanese Society of Clinical Neuropsychopharmacology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Constipation is one of the most common adverse effects in schizophrenia treatment, and it can sometimes cause severe gastrointestinal disease. However, the results of association studies between constipation and psychotropic medications in patients with schizophrenia are inconsistent. Therefore, we investigated the characteristics of psychotropic and laxative prescriptions at discharge in patients with schizophrenia to clarify the association between psychotropics and constipation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed the data of 139 patients with schizophrenia with or without laxative prescriptions at discharge from eight institutions in 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010two patients were prescribed laxatives at discharge. The prescription of benzodiazepines in the laxative use group (66.1%) was significantly higher than that in the non\u2010laxative use group (39.0%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.4\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      ), and the mean number of benzodiazepines in the laxative use group (1.2\u2009\u00b1\u20091.1\/day) was significantly higher than that in the non\u2010laxative use group (0.7\u2009\u00b1\u20090.9\/day) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20092.6\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      ). Multivariate logistic regression analyses revealed that benzodiazepine prescriptions were significantly associated with laxative usage (odds ratio, 3.059; 95% confidence interval, 1.523\u20136.144;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20092.0\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Benzodiazepines may be associated with constipation in patients with schizophrenia. Therefore, clinicians should be cautious when prescribing benzodiazepines for the treatment of schizophrenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.12499","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T14:39:43Z","timestamp":1730990383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The association between benzodiazepine prescriptions and the risk of laxative use in schizophrenia treatment"],"prefix":"10.1002","volume":"45","author":[{"given":"Shinichiro","family":"Ochi","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Molecules and Function Ehime University Graduate School of Medicine  Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kyorin University School of Medicine  Tokyo 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