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Subtype\u2010nonselective opioid receptor antagonists, such as naltrexone (NTX), have been reported to suppress METH addiction, but unclear are the opioid receptor subtypes that are involved in this beneficial effect. To clarify the role of \u03bc\u2010opioid receptors (MOPs), we examined effects of the novel nonpeptidic MOP\u2010selective antagonist UD\u2010030 on the acquisition and expression of METH\u2010induced conditioned place preference (CPP) using behavioral tests in C57BL\/6J mice. UD\u2010030 was found to inhibit both the acquisition and expression of METH\u2010induced CPP in a dose\u2010dependent manner, with effects comparable to those observed with NTX. These findings suggest that UD\u2010030 has the potential to mitigate METH\u2010related reward mechanisms and may serve as a promising candidate for MOP\u2010selective pharmacotherapy targeting METH addiction.<\/jats:p>","DOI":"10.1002\/npr2.12503","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:25:00Z","timestamp":1732681500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibitory effects of the selective \u03bc\u2010opioid receptor antagonist\n                    <scp>UD<\/scp>\n                    \u2010030 on methamphetamine\u2010induced conditioned place preference"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9112-2841","authenticated-orcid":false,"given":"Soichiro","family":"Ide","sequence":"first","affiliation":[{"name":"Addictive Substance Project Tokyo Metropolitan Institute of Medical Science  Tokyo 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