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This study aimed to investigate the relationship between stress\u2010induced weight loss and autophagy\u2010related gene expression in a mouse model of depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Male C57BL\/6 mice were subjected to a chronic immobilization stress (CIS) protocol for 14\u2009days to induce depressive\u2010like behavior. Body weight was measured before and after the CIS, and depressive\u2010like behavior was assessed using the tail suspension test (TST). The expression levels of autophagy\u2010related genes (\n                      <jats:italic>Atg5<\/jats:italic>\n                      ,\n                      <jats:italic>Atg7<\/jats:italic>\n                      ,\n                      <jats:italic>Atg12<\/jats:italic>\n                      ,\n                      <jats:italic>Becn1<\/jats:italic>\n                      ,\n                      <jats:italic>Mmp9<\/jats:italic>\n                      ,\n                      <jats:italic>Fkbp5<\/jats:italic>\n                      , and\n                      <jats:italic>Map1lc3b<\/jats:italic>\n                      ) in the hippocampus and midbrain were evaluated using reverse transcription\u2010quantitative PCR (RT\u2010qPCR). Serum cortisol levels were also measured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The CIS resulted in significant weight loss and increased immobility time in the TST, indicating depressive\u2010like behavior. Serum cortisol levels were not different between CIS\u2010depression model and control mice. In the hippocampus, the expression levels of\n                      <jats:italic>Fkbp5<\/jats:italic>\n                      ,\n                      <jats:italic>Mmp9<\/jats:italic>\n                      , and\n                      <jats:italic>Map1lc3b<\/jats:italic>\n                      were significantly higher in CIS\u2010depression model mice than in control mice. In the midbrain, the expression levels of\n                      <jats:italic>Fkbp5<\/jats:italic>\n                      and\n                      <jats:italic>Mmp9<\/jats:italic>\n                      were significantly higher in CIS\u2010depression model mice than in control mice. Increased autophagy\u2010related gene expressions in CIS\u2010depression model mice were consistent with the previous studies in the postmortem brains of patients with depression. A significant negative correlation was also found between\n                      <jats:italic>Fkbp5<\/jats:italic>\n                      mRNA expression in the hippocampus and the weight change ratio before and after the CIS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings suggest that enhanced autophagy may be related to the pathology of depression and that Fkbp5, an autophagy regulator, mediates stress\u2010induced weight loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.12515","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T22:42:11Z","timestamp":1734993731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association Between Stress\u2010Induced Weight Loss and Autophagy\u2010Related Gene Expression in the Hippocampus and Midbrain of Depression Model Mice"],"prefix":"10.1002","volume":"45","author":[{"given":"Hiroaki","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Molecules and Function Ehime University Graduate School of Medicine  Toon Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Molecules and Function Ehime University Graduate School of Medicine  Toon Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Okano","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Molecules and Function Ehime University Graduate School of Medicine  Toon Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Funahashi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Molecules and Function Ehime University Graduate 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