{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:35Z","timestamp":1786978415068,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to investigate the association between blood fatty acid fractions and posttraumatic stress disorder (PTSD) judgment in individuals who have experienced physical trauma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients admitted to the emergency department for trauma, excluding those with brain damage or serious psychiatric disorders, were enrolled. Blood samples were collected on admission, and PTSD symptoms were assessed using a questionnaire 1 and 3\u2009months after the injury. Multiple regression analysis was used to evaluate the association between fatty acids and Posttraumatic Diagnostic Scale severity scores, adjusting for age, sex, the Childhood Trauma Questionnaire (CTQ), and the use of psychotropic medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significant association was observed between certain fatty acids and PTSD judgment. Mann\u2010Whitney U test results revealed that arachidonic acid was associated with PTSD judgment at 1 month and palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, eicosenoic acid, and eicosadiene acid with PTSD judgment at 3 months. Multiple regression analysis revealed that stearic acid, linoleic acid, arachidic acid, docosatetraenoic acid, lignoceric acid, docosahexaenoic acid, and total omega\u20106 fatty acids (\u03c96) were associated with PTSD judgment after 1\u2009month after trauma. In contrast, only linoleic acid and total \u03c96 were associated with PTSD judgment 3\u2009months after trauma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study is the first to enroll patients with general physical trauma and examine the relationship between fatty acids and PTSD. The findings suggest a potential relationship between blood fatty acid fractions and the development of PTSD symptoms in individuals who have experienced physical trauma. However, further research is needed to confirm and expand on these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.12522","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T02:57:04Z","timestamp":1739847424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Longitudinal Study of the Association of Blood Unsaturated Fatty Acids With Posttraumatic Stress Disorder (\n                    <scp>PTSD<\/scp>\n                    )"],"prefix":"10.1002","volume":"45","author":[{"given":"Tomoko","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Psychiatry Kitasato University, School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Behavioral Medicine, National Institute of Mental Health National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7022-2141","authenticated-orcid":false,"given":"Zui","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Behavioral Medicine, National Institute of Mental Health National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Molecular Therapy, National Institute of Neuroscience National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Asari","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Behavioral Medicine, National Institute of Mental Health National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Kim","sequence":"additional","affiliation":[{"name":"Emeritus Director General, National Institute of Mental Health National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-4588","authenticated-orcid":false,"given":"Ken","family":"Inada","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kitasato University, School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"Guze S. 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