{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:13:39Z","timestamp":1773850419221,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine treatment persistence rates of paliperidone palmitate 3\u2010month (PP3M) for schizophrenia in Japan because evidence in real\u2010world settings is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective population\u2010based cohort study was conducted using the Japan Medical Data Center claims database. The overall cohort comprised schizophrenia patients aged \u2265\u200918\u2009years, who received paliperidone palmitate 1\u2010month (PP1M) within 180\u2009days before initiating PP3M. Of patients in the overall cohort, those who received PP1M \u2265\u20094 times within 180\u2009days at 21\u201342\u2010day intervals with the same dosage strength as the last two PP1M doses before switching to PP3M initiated PP3M with a dose equivalent to 3.5\u2010fold the last PP1M dose and took no other concomitant antipsychotics within 112\u2009days before initiating PP3M were included in the per protocol cohort (PPC). The Kaplan\u2013Meier method was used to calculate PP3M persistence rates in the overall cohort and PP3M monotherapy persistence rates in the PPC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the overall cohort and PPC, 121 patients and 87 patients, with a mean age of 41.5\u2009years and 48%\u201353% being employed, were followed up for \u2264\u200927\u2009months. At 365\u2009days and 730\u2009days, the PP3M persistence rate was 76.9% and 71.7% in the overall cohort, and that for PP3M monotherapy was 73.1% and 64.6% in the PPC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment persistence rates for PP3M in Japan were relatively high among schizophrenia patients transitioned from PP1M. High persistence rates can be achieved with PP3M monotherapy in patients who have been sufficiently stabilized with PP1M monotherapy prior to initiating PP3M.<\/jats:p><\/jats:sec>","DOI":"10.1002\/npr2.70019","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T06:19:59Z","timestamp":1747117199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatment Persistence of Paliperidone Palmitate 3\u2010Month in Patients With Schizophrenia: A Japan Medical Data Center Claims Database Analysis"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-8324","authenticated-orcid":false,"given":"Akihide","family":"Wakamatsu","sequence":"first","affiliation":[{"name":"Medical Affairs Division Janssen Pharmaceutical K.K.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3198-3962","authenticated-orcid":false,"given":"Madoka","family":"Chinen","sequence":"additional","affiliation":[{"name":"Medical Affairs Division Janssen Pharmaceutical K.K.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Horio","sequence":"additional","affiliation":[{"name":"Medical Affairs Division Janssen Pharmaceutical K.K.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1813-0626","authenticated-orcid":false,"given":"Chih\u2010Lin","family":"Chiang","sequence":"additional","affiliation":[{"name":"Medical Affairs Janssen Pharmaceutical of Johnson &amp; Johnson  Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9556-5736","authenticated-orcid":false,"given":"Natsuko","family":"Tokushige","sequence":"additional","affiliation":[{"name":"Medical Affairs Division Janssen Pharmaceutical K.K.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9186-524X","authenticated-orcid":false,"given":"Yosuke","family":"Saga","sequence":"additional","affiliation":[{"name":"Medical Affairs Division Janssen Pharmaceutical K.K.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"\u201cPaliperidone Palmitate 3\u2010Month Janssen Package Insert 2024 [Internet] [In Japanese].\u201dhttps:\/\/www.pmda.go.jp\/PmdaSearch\/iyakuDetail\/ResultDataSetPDF\/800155_1179409G6027_1_03."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2021.1882412"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.22.1017"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/10398562221142453"},{"issue":"3","key":"e_1_2_12_6_1","first-page":"231","article-title":"Analysis of Real\u2010World Data of 3\u2010Month Formulation of Paliperidone Palmitate Using Japan Medical Data Center (JMDC) Claims Database","volume":"73","author":"Chinen M.","year":"2024","journal-title":"Journal of New REM and Clinical"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20090066"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgf2.367"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2021.2243"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2024.13"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/npr2.12473"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S322880"}],"container-title":["Neuropsychopharmacology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.70019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T08:07:56Z","timestamp":1750838876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/npr2.70019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,12]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/npr2.70019"],"URL":"https:\/\/doi.org\/10.1002\/npr2.70019","archive":["Portico"],"relation":{},"ISSN":["2574-173X","2574-173X"],"issn-type":[{"value":"2574-173X","type":"print"},{"value":"2574-173X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,12]]},"assertion":[{"value":"2025-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70019"}}