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While the potential for stimulants to induce psychosis\u2010like or mania\u2010like symptoms in children has been recognized for decades, there have been no reported cases of increased recall of negative memories associated with methylphenidate. Here, we present a rare case in which an initial dose of 18\u2009mg of Methylphenidate Hydrochloride Extended\u2010Release Tablets led to increased recall of negative life events in a 6\u2010year\u2010old child with ADHD. Interestingly, the symptom resolved spontaneously the following day without discontinuing the medication, suggesting that it was an adaptive response rather than a toxic reaction.<\/jats:p>","DOI":"10.1002\/npr2.70026","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T08:54:00Z","timestamp":1747644840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Increased Recall of Negative Memories Following Initial Methylphenidate Administration in a 6\u2010Year\u2010Old Boy With <scp>ADHD<\/scp>: A Case Report"],"prefix":"10.1002","volume":"45","author":[{"given":"Qingqing","family":"Xiang","sequence":"first","affiliation":[{"name":"Child and Adolescent Psychosomatic Medicine Center Zigong Mental Health Center  Zigong China"},{"name":"The Zigong Affiliated Hospital Southwest Medical University  Zigong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liling","family":"Xu","sequence":"additional","affiliation":[{"name":"The Zigong Affiliated Hospital Southwest Medical University  Zigong China"},{"name":"Department of Auxiliary Examination Zigong Mental Health Center  Zigong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Feng","sequence":"additional","affiliation":[{"name":"The Zigong Affiliated Hospital Southwest Medical University  Zigong China"},{"name":"Department of Auxiliary Examination Zigong Mental Health Center  Zigong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anhong","family":"Ye","sequence":"additional","affiliation":[{"name":"The Zigong Affiliated Hospital Southwest Medical University  Zigong China"},{"name":"Research Center for Psychiatry Zigong Institute of Brain Science  Zigong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1797-1069","authenticated-orcid":false,"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"The Zigong Affiliated Hospital Southwest Medical University  Zigong China"},{"name":"Research Center for Psychiatry Zigong Institute of Brain Science  Zigong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youguo","family":"Tan","sequence":"additional","affiliation":[{"name":"The Zigong Affiliated Hospital Southwest Medical University  Zigong China"},{"name":"Research Center for Psychiatry Zigong Institute of Brain Science  Zigong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00238-X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.6.942"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.048827"},{"issue":"11","key":"e_1_2_10_5_1","article-title":"Methylphenidate for Children and Adolescents With Attention Deficit Hyperactivity Disorder (ADHD)","volume":"3","author":"Storeb\u00f8 O. 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