{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:03:42Z","timestamp":1787670222883,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Benzodiazepine and non\u2010benzodiazepine hypnotics (Z\u2010drugs) are known risk factors for adverse events, including delirium and falls. Although formularies are intended to promote appropriate prescribing, few comprehensive studies have assessed their clinical impact in the context of sleep medications. This study aimed to evaluate changes in hypnotic prescribing patterns and associated clinical outcomes following the implementation of a sleep medication formulary. A psychiatric liaison team developed and implemented a formulary in April 2024, recommending lemborexant as the first\u2010line treatment and eszopiclone as the second\u2010line option. This single\u2010center, retrospective study compared patients admitted and discharged during the 12\u2009months before (April 2023 to March 2024;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200912\u2009633) and after (April 2024 to March 2025;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200912\u2009931) implementation. Outcome measures included monthly prescription volumes, diazepam equivalents, use in clinical pathways and prescription sets, delirium incidence, nighttime falls, and length of hospital stay. Statistical analyses were performed using the Mann\u2013Whitney\n                    <jats:italic>U<\/jats:italic>\n                    \u2010test and Fisher's exact test. Following implementation, prescription volumes of lemborexant and eszopiclone increased significantly, whereas diazepam equivalents decreased from 10\u2009682\u2009mg to 4117\u2009mg. All 104 clinical pathways and prescription sets previously using benzodiazepine hypnotics or Z\u2010drugs were converted to lemborexant. Monthly delirium cases declined from 12.5 to 8.0, and the proportion of nighttime falls among patients receiving benzodiazepine hypnotics or Z\u2010drugs decreased from 24.0% to 11.5%. The median hospital stay also decreased from 8 to 7\u2009days. These findings suggest that formulary implementation effectively optimized hypnotic prescribing and contributed to improved clinical outcomes and patient safety in an acute care setting.\n                  <\/jats:p>","DOI":"10.1002\/npr2.70054","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T23:01:09Z","timestamp":1757372469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Lemborexant\u2010Based Sleep Medication Formulary on Benzodiazepine Reduction and Clinical Outcomes: A Single\u2010Center Retrospective Study"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6539-1932","authenticated-orcid":false,"given":"Shunya","family":"Aoki","sequence":"first","affiliation":[{"name":"Pharmaceutical Department Japanese Red Cross Narita Hospital  Narita Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutoshi","family":"Takada","sequence":"additional","affiliation":[{"name":"Pharmaceutical Department Japanese Red Cross Narita Hospital  Narita Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuru","family":"Sugama","sequence":"additional","affiliation":[{"name":"Pharmaceutical Department Japanese Red Cross Narita Hospital  Narita Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsugi","family":"Kimiwada","sequence":"additional","affiliation":[{"name":"Pharmaceutical Department Japanese Red Cross Narita Hospital  Narita Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Nursing Department Japanese Red Cross Narita Hospital  Narita Chiba 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