{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T08:04:52Z","timestamp":1766390692982,"version":"3.48.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["970727"],"award-info":[{"award-number":["970727"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n The use of complementary and alternative medicine has gained traction in the treatment of psychiatric disorders, including obsessive\u2010compulsive disorder (OCD). This trial investigates the efficacy of an herbal combination of\n Echium amoenum<\/jats:italic>\n L. and\n Rheum ribes<\/jats:italic>\n in reducing OCD symptoms.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this triple\u2010blind, randomized, controlled clinical trial, 40 participants were assigned to either the intervention group, receiving a daily dose of 30\u2009mL of the herbal syrup, or a control group receiving a placebo. OCD severity was measured using the Yale\u2010Brown Obsessive Compulsive Scale (Y\u2010BOCS) at baseline, and at 4, 6, and 8\u2009weeks. Side effects were monitored based on a preestablished checklist. Data were analyzed using SPSS v 16.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There was no significant difference between groups in age (\n p<\/jats:italic>\n \u2009=\u20090.214) and sex (\n p<\/jats:italic>\n \u2009=\u20091.00). The change in OCD scores between times significantly differed in the intervention group (\n p<\/jats:italic>\n \u2009=\u20090.037). However, the OCD score did not change significantly during the time in the control group (\n p<\/jats:italic>\n \u2009=\u20090.932). Moreover, there was no significant difference between the two groups at each time. However, the trend of changes during the trial was significant between the groups (\n p<\/jats:italic>\n \u2009<\u20090.001). Additionally, no adverse effects were reported among participants consuming the herbal syrup.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study provides evidence that\n Echium amoenum<\/jats:italic>\n L. and\n Rheum ribes<\/jats:italic>\n can effectively decrease OCD severity without adverse effects, suggesting their potential as a safe treatment option. Future research with larger sample sizes and longer follow\u2010up periods is warranted to confirm these findings and explore the mechanisms of action.\n <\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n Iranian Registry for Clinical Trials (registration number: IRCT20200712048088N1)<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/npr2.70073","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T10:15:17Z","timestamp":1763374517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effectiveness of Herbal Mixture of\n Echium amoenum<\/i>\n L. and\n Rheum ribes<\/i>\n on Obsessive\u2010Compulsive Disorder: A Randomized Controlled Triple\u2010Blind Clinical Trial"],"prefix":"10.1002","volume":"45","author":[{"given":"Ali","family":"Talaei","sequence":"first","affiliation":[{"name":"Psychiatry and Behavioral Sciences Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ala","family":"Masiha","sequence":"additional","affiliation":[{"name":"Psychiatry and Behavioral Sciences Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7413-6945","authenticated-orcid":false,"given":"Fahimeh","family":"Afzaljavan","sequence":"additional","affiliation":[{"name":"Psychiatry and Behavioral Sciences Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Reza","family":"Noras","sequence":"additional","affiliation":[{"name":"Department of Persian Medicine, School of Complementary and Persian Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2118-1096","authenticated-orcid":false,"given":"Hasan","family":"Rakhshandeh","sequence":"additional","affiliation":[{"name":"Pharmacological Research Center of Medicinal Plants Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lida","family":"Jarahi","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1015-1031","authenticated-orcid":false,"given":"Kiana","family":"Sedighi","sequence":"additional","affiliation":[{"name":"Psychiatry and Behavioral Sciences Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0270184"},{"key":"e_1_2_12_3_1","first-page":"35","volume-title":"Obsessive\u2010Compulsive Disorder and Tourette's Syndrome","author":"Horwath E.","year":"2022"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12101309"},{"issue":"11","key":"e_1_2_12_5_1","article-title":"Obsessive\u2010Compulsive Disorder (OCD): A Comprehensive Review of Diagnosis, Comorbidities, and Treatment Approaches","volume":"15","author":"Singh 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the Effects of a Herbal Drug Based on Echium Amoenum With Fluvoxamine in the Treatment of Adolescents With Obsessive\u2010Compulsive Disorder","volume":"19","author":"Noras M. R.","year":"2022","journal-title":"Current Drug Discovery Technologies"},{"issue":"3","key":"e_1_2_12_25_1","first-page":"57","article-title":"Efficacy of Hydroalcoholic Extract of Rheum ribes L. in Treatment of Obsessive Compulsive Disorder: A Double Blind Clinical Trial","volume":"1","author":"Sayyah M.","year":"2011","journal-title":"Journal of Pharmaceutical and Biomedical Sciences"}],"container-title":["Neuropsychopharmacology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.70073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T07:59:57Z","timestamp":1766390397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/npr2.70073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/npr2.70073"],"URL":"https:\/\/doi.org\/10.1002\/npr2.70073","archive":["Portico"],"relation":{},"ISSN":["2574-173X","2574-173X"],"issn-type":[{"type":"print","value":"2574-173X"},{"type":"electronic","value":"2574-173X"}],"subject":[],"published":{"date-parts":[[2025,11,17]]},"assertion":[{"value":"2025-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70073"}}