{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T21:31:43Z","timestamp":1785015103188,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18dm0307002"],"award-info":[{"award-number":["JP18dm0307002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21dk0307103"],"award-info":[{"award-number":["JP21dk0307103"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21wm0425012"],"award-info":[{"award-number":["JP21wm0425012"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22tm0424222"],"award-info":[{"award-number":["JP22tm0424222"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24dk0307132"],"award-info":[{"award-number":["JP24dk0307132"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24WM0625302"],"award-info":[{"award-number":["JP24WM0625302"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008667","name":"SENSHIN Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We previously performed data\u2010driven classification based on large\u2010scale neuroimaging datasets to identify a potential novel subtype of psychiatric disorders characterized by the pronounced enlarged ventricles and cognitive impairment (EVCI) in one cohort. However, these findings have yet to be validated across independent cohorts. Herein, we investigated the availability of cognitive data in other cohorts in the Cognitive Genetics Collaborative Research Organization (COCORO) project to assess the presence of cognitive impairment (CI). Subsequently, we compared the prevalence of CI, lateral ventricular volume, and demographic and clinical characteristics between individuals with EVCI and those with EV but without CI (EV\u2010nonCI). Cognitive data were available for 27 individuals with EVCI from the other 8 cohorts. Among the 27 individuals in the EV group, 5 (18.5%) exhibited EVCI, all of whom were diagnosed with schizophrenia. Three individuals (60%) in the EVCI group were male. Compared with the EV\u2010non\u2010CI group, the EVCI group presented significantly lower current intellectual quotient (IQ) scores (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20095.8\u2009\u00d7\u200910\n                    <jats:sup>\u22124<\/jats:sup>\n                    ), but there was no significant difference in premorbid IQ (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.56). Furthermore, there was no significant difference in the\n                    <jats:italic>Z<\/jats:italic>\n                    scores for lateral ventricular volume between the groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.26). This study validated the existence of the EVCI subgroup in independent cohorts, thus supporting our previous findings.\n                  <\/jats:p>","DOI":"10.1002\/npr2.70078","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:31:11Z","timestamp":1768447871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Data\u2010Driven Psychiatric Disorder Subtype Defined by Significant Enlarged Ventricles and Cognitive Impairment: A Replication Study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6583-6405","authenticated-orcid":false,"given":"Toshiaki","family":"Onitsuka","sequence":"first","affiliation":[{"name":"NHO Sakakibara National Hospital  Tsu Mie Japan"},{"name":"Department of Neuropsychiatry, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2746-1590","authenticated-orcid":false,"given":"Yuka","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Life Grow Brilliant Mental Clinic, Medical Corporation Foster  Osaka Osaka Japan"},{"name":"Department of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4720-3166","authenticated-orcid":false,"given":"Satsuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"International Research Center for Neurointelligence (WPI\u2010IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS) The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeri","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9577-9640","authenticated-orcid":false,"given":"Kazutaka","family":"Ohi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Gifu University Graduate School of Medicine  Gifu Gifu Japan"},{"name":"Department of General Internal Medicine Kanazawa Medical University  Uchinada Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry University of Toyama Graduate School of Medicine and Pharmaceutical Sciences  Toyama Japan"},{"name":"Research Center for Idling Brain Science University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hokkaido University Graduate School of Medicine  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8492-1533","authenticated-orcid":false,"given":"Harumasa","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry  Tokyo Japan"},{"name":"Department of Clinical Neuroimaging Integrative Brain Imaging Center, National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7637-5576","authenticated-orcid":false,"given":"Reiji","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Occupational and Environmental Health  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Division of Neuropsychiatry, Department of Neuroscience Yamaguchi University Graduate School of Medicine  Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Yamasue","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hamamatsu University School of Medicine  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusuke","family":"Numata","sequence":"additional","affiliation":[{"name":"Department of 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