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To examine the physiological and pathophysiological roles of GPR143, we analyzed the behavior of\n                    <jats:italic>Gpr143<\/jats:italic>\n                    gene\u2010deficient (\n                    <jats:italic>Gpr143<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/y<\/jats:italic>\n                    <\/jats:sup>\n                    ) mice. We performed comprehensive behavioral analyses including the prepulse inhibition test, sucrose preference test, light\u2013dark exploration test, etc. and microarray analysis.\n                    <jats:italic>Gpr143<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/y<\/jats:italic>\n                    <\/jats:sup>\n                    mice displayed a mixed psychosis\u2010like phenotype: impaired prepulse inhibition (a characteristic of schizophrenia) combined with reward system aberrations, depression, and heightened aggression (characteristic of mood disorders). By microarray analysis, we identified 17 downregulated and 20 upregulated genes in the forebrain of\n                    <jats:italic>Gpr143<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/y<\/jats:italic>\n                    <\/jats:sup>\n                    mice, genes putatively involved in serotonergic and\/or dopaminergic transmission. These findings suggest that GPR143 plays a role in mesolimbic and mesocortical functions underlying sensory gating, reward, social hierarchy, cognition, and emotional regulation. These data further suggest both a new animal model and a unique therapeutic focus for a heretofore difficult to study and treat mixed psychosis\u2010like condition.\n                  <\/jats:p>","DOI":"10.1002\/npr2.70080","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T10:43:46Z","timestamp":1767955426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disruption of the\n                    <scp>l<\/scp>\n                    \u2010\n                    <scp>DOPA<\/scp>\n                    Receptor\n                    <i>Gpr143\/OA1<\/i>\n                    \u2010Gene in Mice Creates a Unique Mixed Psychosis\u2010Like Phenotype"],"prefix":"10.1002","volume":"46","author":[{"given":"Yoshio","family":"Goshima","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology and Neurobiology Yokohama City University Graduate School of Medicine  Yokohama 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