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In this study, we investigated the effects of this SNP on pain\u2010related phenotypes in patients who underwent laparoscopic gynecologic surgery (LGS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We studied 333 Japanese women, 21\u201369\u2009years, who underwent LGS at Juntendo University Hospital between 2017 and 2019. We evaluated associations between SNP genotypes and postoperative pain\u2010related phenotypes, including fentanyl requirements, rescue analgesic requirements, and the average pain scores on an 11\u2010point Numeric Rating Scale (NRS) during the 24\u2010h postoperative period. Patients with the TT or CT genotype were compared with those with the CC genotype using the Mann\u2013Whitney test or\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      test. Values of\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 were considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The minor T allele frequency was 34.1%. Patients with the CT or TT genotype reported significantly lower average NRS pain scores (median, 1.6 vs. 2.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031) and required fewer rescue analgesics (5.5% vs. 15.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) compared to those with the CC genotype. Postoperative fentanyl requirements did not differ between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.940).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The minor T allele of the rs7858836 SNP was significantly associated with lower postoperative pain intensity, albeit only slightly, and decreased the need for rescue analgesics under comparable fentanyl dosing conditions, potentially reflecting lower pain sensitivity. However, the magnitude of the effect was less than our previous findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.70083","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T03:45:13Z","timestamp":1766461513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of the rs7858836 Single\u2010Nucleotide Polymorphisms of the\n                    <scp>\n                      <i>ASTN2<\/i>\n                    <\/scp>\n                    Gene on Pain\u2010Related Phenotypes in Japanese Women Who Underwent Laparoscopic Gynecologic Surgery"],"prefix":"10.1002","volume":"46","author":[{"given":"Rie","family":"Inoue","sequence":"first","affiliation":[{"name":"Addictive Substance Project Tokyo Metropolitan Institute of Medical Science  Tokyo 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