{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:06:48Z","timestamp":1779692808587,"version":"3.53.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Kleine\u2013Levin syndrome (KLS) is a rare disorder with limited literature on treatment options and efficacy, especially in adolescents. We report a 12\u2010year\u2010old patient with KLS who had a favorable response to clarithromycin therapy. In this unique case of KLS, both central hypopneas and a novel manifestation of REM sleep without atonia (RSWA) emerged during the episode and resolved with clarithromycin, suggesting a modulatory role on brainstem sleep networks and a possible neurophysiologic effect of clarithromycin therapy. However, reactions to pharmacologic treatment in individual KLS cases remain highly variable. Therefore, we compiled and summarized the available evidence to assist clinicians in evaluating potential therapeutic options.<\/jats:p>","DOI":"10.1002\/npr2.70087","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:15:43Z","timestamp":1767676543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacologic Treatment of Kleine\u2013Levin Syndrome: A Case Report and Comprehensive Review of Therapeutic Options"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2988-9384","authenticated-orcid":false,"given":"Sarisa","family":"Thawongit","sequence":"first","affiliation":[{"name":"Siriraj Sleep Center, Faculty of Medicine, Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vorasith","family":"Siripornpanich","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"},{"name":"Research Center for Neuroscience, Institute of Molecular Biosciences Mahidol University  Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunliya","family":"Thampratankul","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"The AASM International Classification of Sleep Disorders\u2013Third Edition, Text Revision (ICSD\u20103 \u2010TR)","year":"2023"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21333"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2005753118"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu112"},{"key":"e_1_2_10_6_1","unstructured":"Genetic and Rare Diseases Information Center \u201cKleine\u2010Levin Syndrome \u201dhttps:\/\/rarediseases.info.nih.gov\/diseases\/3117\/kleine\u2010levin\u2010syndrome."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000036605.89977.D0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000304133.00875.2b"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2001.00272.x"},{"key":"e_1_2_10_10_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, Version 3.0","author":"Berry R. 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