{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:43:00Z","timestamp":1783096980305,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Late\u2010life patients with depression are reportedly less responsive to antidepressant treatment than younger patients. Additionally, patients who have depression comorbid with Alzheimer's disease (AD) and those with an amyloid \u03b2 (A\u03b2) burden have shown a poor response to antidepressant treatment, suggesting that AD pathology may contribute to treatment resistance. A recent report indicated that A\u03b2 oligomers in blood have increased in patients with AD and are associated with AD pathology. This study was performed to reveal the relationship between blood A\u03b2 oligomers and the response to antidepressant treatment in middle\u2010aged and late\u2010life patients with depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this observational study, serum levels of A\u03b240, A\u03b242, and A\u03b2 oligomers were evaluated in 80 inpatients with major depressive disorder aged \u2265\u200940\u2009years. Depressive symptoms were assessed at admission (baseline) and after 4\u2009weeks of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were significantly fewer treatment responders among patients with than without serum A\u03b2 oligomers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016). Serum A\u03b2 oligomers were found to influence the treatment response even after control for age, sex, number of depressive episodes, severity of depression, and Mini\u2010Mental State Examination scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggest that serum A\u03b2 oligomers may predict a poor response to antidepressant treatment in middle\u2010aged and late\u2010life patients with depression. Our findings also lead us to speculate that elderly patients with a poor treatment response may share AD\u2010related pathophysiological features or neural vulnerability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.70109","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:50:55Z","timestamp":1773647455000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum Amyloid \u03b2 Oligomer May Predict Treatment Response in Middle\u2010Aged and Late\u2010Life Patients With Depression"],"prefix":"10.1002","volume":"46","author":[{"given":"Kentaro","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Science Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Psychiatry Juntendo University Koshigaya Hospital  Saitama 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