{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:49:27Z","timestamp":1782388167472,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Oxidative stress has recently emerged as a key factor in the pathophysiology of schizophrenia. This study investigated whether inhalation therapy with hydrogen gas, a selective antioxidant, could reduce oxidative stress and improve behavioral outcomes in an MK\u2010801\u2013induced schizophrenia\u2010like mouse model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six\u2010week\u2010old male C57BL\/6 mice received chronic intraperitoneal injections of MK\u2010801 (0.5\u2009mg\/kg) or saline for 4\u2009weeks. A third group received MK\u2010801 followed by hydrogen gas inhalation therapy. Behavioral assessments included the open\u2010field test (OFT) to evaluate hyperactivity as an indicator of positive symptoms and the prepulse inhibition (PPI) test to assess cognitive dysfunction. Oxidative stress was evaluated by measuring whole\u2010brain hydroxyl radical antioxidant capacity (HORAC) and total antioxidant capacity (TAC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MK\u2010801\u2013treated mice exhibited significant hyperactivity in the OFT and a trend toward impaired PPI, confirming the schizophrenia\u2010like phenotype. Hydrogen gas treatment did not produce significant improvements. MK\u2010801 administration significantly reduced HORAC levels, whereas hydrogen gas therapy markedly restored them. No significant differences in TAC were observed among the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that hydrogen gas therapy does not significantly ameliorate behavioral abnormalities in the MK\u2010801\u2013induced schizophrenia\u2010like mouse model but exerts beneficial antioxidant effects. Future studies should evaluate hydrogen gas as an adjunctive therapy and further assess its efficacy and safety in clinical settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.70117","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:39:38Z","timestamp":1775561978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydrogen Gas Therapy in Schizophrenia: Potential Neuroprotective Effects From an Animal Study"],"prefix":"10.1002","volume":"46","author":[{"given":"Nobumi","family":"Miyake","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"},{"name":"Department of Neuropsychiatry Kawasaki Tama Municipal Hospital  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Haga","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010Ichi","family":"Hirano","sequence":"additional","affiliation":[{"name":"Independent Researcher  Chigasaki Japan"},{"name":"Department of Research and Development MIZ Company Limited  Kamakura Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2526-4681","authenticated-orcid":false,"given":"Yusuke","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Research and Development MIZ Company Limited  Kamakura Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyo","family":"Oguchi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Student Health Center Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.47"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.11.1474"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800190080012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10673229609017192"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1300.008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3371\/CSRP.6.3.4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.03.018"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.11.006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16549"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2022.114429"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.870032"},{"issue":"15","key":"e_1_2_10_14_1","first-page":"2137","article-title":"Potential Role of Some Oxidant\/Antioxidant Status Parameters in Prefrontal Cortex of Rat Brain in an Experimental Psychosis Model and the Protective Effects of Melatonin","volume":"18","author":"Ozyurt H.","year":"2014","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.01.029"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/2045-9912.296045"},{"issue":"5","key":"e_1_2_10_17_1","article-title":"Cannabidiol Attenuates Sensorimotor Gating Disruption and Molecular Changes Induced by Chronic Antagonism of NMDA Receptors in Mice","volume":"18","author":"Gomes F. 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