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Nicotine and ethanol are frequently co\u2010used among adolescents, and converging evidence suggests that these drugs interact to modulate mesolimbic dopamine transmission. The present study investigated how chronic exposure to nicotine, ethanol, or their combination during adolescence influences adult conditioned place preference (CPP) for nicotine. Male Wistar\u2010Imamichi rats were assigned to four groups: Control (no drug exposure), Nicotine (0.20\u2009mg\/kg\/day, s.c., PND 28\u201341), EtOH (voluntary 20% ethanol intake), and Co\u2010use (nicotine + ethanol). After maturation, all animals underwent CPP with 0.08\u2009mg\/kg nicotine using an unbiased procedure. We hypothesized that adolescent drug exposure would enhance vulnerability to nicotine reward in adulthood. Contrary to this hypothesis, only the Control group exhibited significant CPP, whereas no nicotine\u2010induced preference was observed in any drug\u2010exposed group. These findings emphasize the complexity of developmental drug interactions and suggest that adolescent exposure to addictive substances does not uniformly increase vulnerability to nicotine reward.<\/jats:p>","DOI":"10.1002\/npr2.70132","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:03:47Z","timestamp":1779260627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adolescent Exposure to Nicotine and Ethanol Attenuates Adult Nicotine Reward Sensitivity in Rats"],"prefix":"10.1002","volume":"46","author":[{"given":"Michimasa","family":"Toyoshima","sequence":"first","affiliation":[{"name":"Laboratory of Psychology and Behavioral Neuroscience, Institute of Human Sciences University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Toyofuku","sequence":"additional","affiliation":[{"name":"Laboratory of Psychology 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