{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:49:28Z","timestamp":1782388168879,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008880","name":"Kanae Foundation for the Promotion of Medical Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014475","name":"Pfizer Health Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014475","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["21gm6310015h0002"],"award-info":[{"award-number":["21gm6310015h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["22gm1510009h0001"],"award-info":[{"award-number":["22gm1510009h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["21wm04250XXs0101"],"award-info":[{"award-number":["21wm04250XXs0101"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["21uk1024002h0002"],"award-info":[{"award-number":["21uk1024002h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23gm1910004s0301"],"award-info":[{"award-number":["23gm1910004s0301"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["22wm0525010h0002"],"award-info":[{"award-number":["22wm0525010h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H04173"],"award-info":[{"award-number":["23H04173"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K15935"],"award-info":[{"award-number":["20K15935"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H05698"],"award-info":[{"award-number":["21H05698"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Given that alterations in oxytocinergic and immune systems have been implicated in the social and emotional difficulties of autism spectrum disorder (ASD), yet the associations between these biological factors and internal psychological constructs remain unclear, we examined the relationship between salivary oxytocin (OT) levels, inflammatory markers (interleukin\u20101\n                      <jats:italic>\u03b2<\/jats:italic>\n                      [IL\u20101\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ], IL\u20106, IL\u20108), self\u2010esteem, and perceived social support in children and adolescents with and without ASD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>26 children and adolescents with ASD and 23 typically developing (TD) controls were included. Salivary OT and inflammatory cytokine levels were measured using enzyme\u2010linked immunosorbent and multiplex immunoassays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Salivary oxytocin levels were significantly lower in the ASD group than in the TD group after adjusting for age. In contrast, no significant group differences were observed in inflammatory markers (IL\u20101\n                      <jats:italic>\u03b2<\/jats:italic>\n                      , IL\u20106, or IL\u20108). However, across participants, including those with ASD, higher OT levels were associated with greater self\u2010esteem and perceived social support. These findings suggest that oxytocin\u2010related socio\u2010emotional processes may be associated with socio\u2010emotional functioning across children and adolescents, including those with ASD. Participants with higher OT levels were associated with greater self\u2010esteem and perceived social support. Among the inflammatory markers, none of the cytokines (IL\u20101\n                      <jats:italic>\u03b2<\/jats:italic>\n                      , IL\u20106, or IL\u20108) showed significant associations with the psychological measures, including AQ\u2010J total scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OT levels may be associated with socio\u2010emotional functioning and psychological well\u2010being across children and adolescents with and without ASD, regardless of diagnostic status. In contrast, no significant associations were observed between inflammatory markers and psychological measures in the present sample.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.70138","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:39:03Z","timestamp":1780591143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salivary Oxytocin and Socio\u2010Emotional Functioning in Children and Adolescents With and Without Autism Spectrum Disorder"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3531-0603","authenticated-orcid":false,"given":"Minobu","family":"Ikehara","sequence":"first","affiliation":[{"name":"Department of Psychiatry Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rio","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kumamoto University  Kumamoto Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4362-3262","authenticated-orcid":false,"given":"Kazuhiko","family":"Yamamuro","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nara Medical University  Nara Japan"},{"name":"Center for Health Control Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuko","family":"Kashida","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kumamoto University  Kumamoto Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nara Medical University  Nara Japan"},{"name":"Department of Neuropsychiatry Kumamoto University  Kumamoto Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Toritsuka","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kumamoto University  Kumamoto Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4339-9413","authenticated-orcid":false,"given":"Manabu","family":"Makinodan","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kumamoto University  Kumamoto Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1024\/1422-4917\/a000098"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2005.12.004"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-024-00635-z"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.919890"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01139-8"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.46747\/cfp.6802103"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00439-3"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.04.117"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-3-16"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.11.031"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-013-1899-3"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.03.025"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12839"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010257"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.08.003"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.01.033"},{"issue":"2","key":"e_1_2_12_18_1","first-page":"229","article-title":"Innate Immune Dysfunction and Neuroinflammation in Autism Spectrum Disorder (ASD)","volume":"22","author":"Hughes H. K.","year":"2024","journal-title":"Focus American Psychiatric Publishing"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-013-9393-4"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020470"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04671"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.10.027"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.10.015"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2011.10.002"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/23969415221147430"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.272"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20315"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1125428"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3978"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.12.002"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.08.007"},{"key":"e_1_2_12_32_1","volume-title":"Autism Diagnostic Observation Schedule, 2nd Ed","author":"Lord G.","year":"2012"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.33588\/rn.3201.2000110"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2005.01403.x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.5926\/jjep1953.30.1_64"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/00223891.1990.9674095"},{"key":"e_1_2_12_37_1","first-page":"65","article-title":"Investigation of the Japanese Version of Rosenberg's Self\u2010Esteem Scale","volume":"12","author":"Sakurai S.","year":"2000","journal-title":"Bulletin of Tsukuba Developmental and Clinical Psychology"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa5201_2"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.04.009"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.09.019"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.10.002"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.06.026"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705521114"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2103583"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.04.017"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.3181"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1312857110"}],"container-title":["Neuropsychopharmacology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.70138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/npr2.70138","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.70138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:24:11Z","timestamp":1782386651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/npr2.70138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/npr2.70138"],"URL":"https:\/\/doi.org\/10.1002\/npr2.70138","archive":["Portico"],"relation":{},"ISSN":["2574-173X","2574-173X"],"issn-type":[{"value":"2574-173X","type":"print"},{"value":"2574-173X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70138"}}