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The present study investigated whether this SNP influences postoperative fentanyl requirements after laparoscopic\u2010assisted colectomy (LAC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We examined 350 Japanese patients who underwent LAC for colorectal cancer. Postoperative pain was managed with an initial intravenous bolus dose of fentanyl, followed by intravenous fentanyl patient\u2010controlled analgesia (PCA). The primary endpoint was the 12\u2010h postoperative fentanyl requirement, defined as the sum of the initial bolus dose and PCA consumption at 12\u2009h postoperatively, which was normalized to body weight. Genotypes of the A118G SNP were obtained from our previous whole\u2010genome genotyping. Associations between genotypes and pain\u2010related phenotypes were analyzed using the Jonckheere\u2013Terpstra test, followed by the Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test. Values of\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 were considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the total cohort, the 12\u2010h postoperative fentanyl requirement was significantly higher in GG homozygotes than in AA homozygotes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022). Among 217 males, it was higher in GG homozygotes than in both AA homozygotes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) and AG heterozygotes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038). In contrast, among 133 females, this endpoint was unaffected by the genotype of the A118G SNP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In patients who underwent LAC, the\n                      <jats:italic>OPRM1<\/jats:italic>\n                      A118G SNP significantly influenced postoperative fentanyl requirements in the total cohort, but this effect was observed only in males. These findings indicate a sex\u2010dependent influence of the A118G SNP on postoperative fentanyl requirements in Japanese patients who underwent LAC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>University Hospital Medical Information Network Clinical Trials Registry (Trial ID: UMIN000003814)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.70140","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:05:45Z","timestamp":1780549545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex Difference in Effect of the\n                    <scp>\n                      <i>OPRM1<\/i>\n                    <\/scp>\n                    Gene\n                    <scp>A118G<\/scp>\n                    (rs1799971) Single\u2010Nucleotide Polymorphism on the Requirement for Postoperative Fentanyl in Japanese Patients Who Underwent Laparoscopic\u2010Assisted Colectomy"],"prefix":"10.1002","volume":"46","author":[{"given":"Hideyuki","family":"Nakagawa","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Saitama Medical University International Medical Center  Hidaka\u2010Shi Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-4651","authenticated-orcid":false,"given":"Daisuke","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Addictive Substance Project Tokyo Metropolitan Institute of Medical Science  Setagaya\u2010ku Tokyo Japan"},{"name":"Department of Neuropsychopharmacology National Institute of Mental Health, National Center of Neurology and Psychiatry  Kodaira Tokyo 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