{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:49:22Z","timestamp":1782388162931,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Prader\u2013Willi syndrome (PWS) is a rare genetic disorder frequently associated with repetitive and self\u2010injurious behaviors such as skin picking. Effective pharmacological treatments for compulsive scratching behavior in PWS remain limited.<\/jats:p>\n <\/jats:sec>\n \n Case Presentation<\/jats:title>\n We report the case of a 19\u2010year\u2010old woman with PWS presenting with severe, persistent scratching behavior resulting in repeated excoriations. Escitalopram produced partial improvement but was discontinued because of sedation. Treatment was switched to vortioxetine, which reduced the frequency of scratching but did not achieve remission. Subsequent augmentation with lurasidone resulted in marked improvement, with episodes decreasing from daily occurrences to once every 1\u20133\u2009months and lasting only a few\u00a0minutes. The patient remained stable for 2\u2009years without recurrence of severe symptoms.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This case suggests that vortioxetine and lurasidone may represent a potential pharmacological option for severe scratching behavior in PWS. Further studies are needed to clarify the therapeutic role of this combination approach.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/npr2.70145","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:08:21Z","timestamp":1781741301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vortioxetine\u2013Lurasidone Augmentation for Compulsive Scratching Behavior in Prader\u2013Willi Syndrome: A Case Report"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5458-3331","authenticated-orcid":false,"given":"Yasuhide","family":"Nagoshi","sequence":"first","affiliation":[{"name":"Department of Psychiatry Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.01.029"},{"issue":"2","key":"e_1_2_11_3_1","first-page":"245","article-title":"Self\u2010Injurious Behavior and Serotonin in Prader\u2010Willi Syndrome","volume":"30","author":"Hellings J. 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