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In recent years, numerous reports have demonstrated that psychedelics are effective in treating various psychiatric disorders such as major depressive disorder (MDD), treatment\u2010resistant depression (TRD), and anxiety\u2010related disorders. We have previously reported that administration of psilocin, the active metabolite of psilocybin, produces antidepressant\u2010like effects in mice. Furthermore, we found that this effect is mediated by 5\u2010HT2AR activation. Since depression and other psychiatric disorders often lead to impairments in social behavior (e.g., social avoidance), the present study examined the effects of psilocin on social avoidance behavior in mice subjected to chronic social defeat stress (CSDS), a widely used model that closely models human psychosocial stress. Mice exposed to CSDS exhibited social avoidance behavior, whereas psilocin administration before the onset of CSDS had little effect on this behavior. In contrast, psilocin administration after the completion of CSDS ameliorated social avoidance in CSDS\u2010exposed mice. This effect was blocked by pretreatment with a 5\u2010HT2AR antagonist, indicating\u00a0that psilocin exerts its therapeutic effects through 5\u2010HT2AR activation. Taken together, psilocin exerts therapeutic effects on social avoidance behavior after stress through activation of 5\u2010HT2AR, but not preventive effects when administered before stress, suggesting that psilocin may promote stress resilience rather than resistance.\n                  <\/jats:p>","DOI":"10.1002\/npr2.70152","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:35:19Z","timestamp":1782858919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Contribution of the Serotonin 5\u2010\n                    <scp>\n                      HT\n                      <sub>2A<\/sub>\n                    <\/scp>\n                    Receptor to the Therapeutic Effect of Psilocin on Social Behavior Deficits in Mice Repeatedly Exposed to Social Defeat 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