{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:51:58Z","timestamp":1791276718057,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K18734"],"award-info":[{"award-number":["24K18734"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K02376"],"award-info":[{"award-number":["24K02376"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K19063"],"award-info":[{"award-number":["25K19063"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25wm0625126"],"award-info":[{"award-number":["JP25wm0625126"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012833","name":"Niigata University","doi-asserted-by":"publisher","award":["25009"],"award-info":[{"award-number":["25009"]}],"id":[{"id":"10.13039\/100012833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Multiple sclerosis (MS) can present with neurological and psychiatric symptoms that may overlap with those of schizophrenia, making differentiation difficult particularly because their typical onset ages are similar. We present the case of a woman in her 50s who developed persecutory delusions and a subjective sense of being under surveillance in Year X\u201031 and was diagnosed with schizophrenia. Despite the long\u2010term antipsychotic treatment, the patient's symptoms persisted and worsened. In Year X\u20101, brain magnetic resonance imaging revealed multiple white matter lesions, and then cerebrospinal fluid analysis revealed oligoclonal bands, leading to a diagnosis of MS. Treatment with ofatumumab was initiated. Owing to persistent psychiatric symptoms, clozapine was administered, which showed partial effectiveness. This case highlights the clinical overlap between schizophrenia and MS and suggests that comorbid MS pathology may be clinically relevant in the context of treatment resistance and cognitive impairment. Similarities in symptoms and disease course raise the possibility that a subset of patients with schizophrenia may share pathophysiological features with MS. In addition, postmortem studies, including our previous and current observations, provide hypothesis\u2010generating support for partially overlapping MS\u2010like changes in some patients with schizophrenia. Clinicians should consider the possibility of comorbid MS in patients with treatment\u2010resistant schizophrenia, particularly when atypical clinical or neurological features are present.<\/jats:p>","DOI":"10.1002\/npr2.70158","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T09:34:51Z","timestamp":1786008891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Possible Contribution of Multiple Sclerosis Pathology to Treatment\u2010Resistant Schizophrenia: A Case Study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2029-2241","authenticated-orcid":false,"given":"Sho","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Psychiatry Tohoku University Hospital  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1159-4436","authenticated-orcid":false,"given":"Atsuko","family":"Nagaoka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tohoku University Hospital  Sendai Miyagi Japan"},{"name":"Department of Neuropsychiatry, School of Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3700-0322","authenticated-orcid":false,"given":"Mizuki","family":"Hino","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, School of Medicine Fukushima Medical University  Fukushima Japan"},{"name":"Department of Disaster Psychiatry, International Research Institute of Disaster Science Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7860-0036","authenticated-orcid":false,"given":"Risa","family":"Shishido","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, School of Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, School of Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Hosogai","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, School of Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9751-0786","authenticated-orcid":false,"given":"Kazusa","family":"Miyahara","sequence":"additional","affiliation":[{"name":"Department of Disaster Psychiatry, International Research Institute of Disaster Science Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Oba","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tohoku University Hospital  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8469-9338","authenticated-orcid":false,"given":"Kimihiko","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Neurology Tohoku University Hospital  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1569-7819","authenticated-orcid":false,"given":"Yasuto","family":"Kunii","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tohoku University Hospital  Sendai Miyagi Japan"},{"name":"Department of Neuropsychiatry, School of Medicine Fukushima Medical University  Fukushima Japan"},{"name":"Department of Disaster Psychiatry, International Research Institute of Disaster Science Tohoku University  Sendai Japan"},{"name":"Department of Psychiatry, Graduate School of Medicine Tohoku University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tohoku University Hospital  Sendai Miyagi Japan"},{"name":"Department of Disaster Psychiatry, International Research Institute of Disaster Science Tohoku University  Sendai Japan"},{"name":"Department of Psychiatry, Graduate School of Medicine Tohoku University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Merritt's Neurology","author":"Rowland L. 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