{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:51:50Z","timestamp":1791276710098,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K14249"],"award-info":[{"award-number":["20K14249"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Behavioral tests in mice and other animals are widely used to study anxiety and to evaluate the efficacy of anxiolytic compounds. However, the validity of behavioral tests used to assess anxiety\u2010like behavior has been questioned because their results are often inconsistent and not readily replicated across studies. We developed a simple falling\u2010trap test to examine whether the number of falls could serve as an index of anxiety\u2010like behavior. The test is designed to produce falls from an elevated path, based on the hypothesis that less\u2010anxious mice would be more prone to fall. Male C57BL\/6N mice were given vehicle or chlordiazepoxide (CDP), and their behavior was evaluated using both the novel test and the elevated plus maze (EPM). The outcomes were the number of falls in the falling\u2010trap test and open\u2010arm time in the EPM. In the falling\u2010trap test, CDP\u2010treated mice did not show a statistically significant increase in the number of falls compared with control mice. In contrast, CDP significantly increased open\u2010arm time in the EPM. Thus, under the present experimental conditions, these findings did not support the hypothesis that the number of falls in the falling\u2010trap test could serve as a measure of anxiety\u2010like behavior. Further studies are needed to determine the conditions under which this assay could be useful and to establish its reliability and validity.<\/jats:p>","DOI":"10.1002\/npr2.70161","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:04:50Z","timestamp":1786716290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lack of Effect of Chlordiazepoxide on the Number of Falls in a Novel Falling\u2010Trap Test in Male\n                    <scp>C57BL<\/scp>\n                    \/\n                    <scp>6N<\/scp>\n                    Mice"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6491-9540","authenticated-orcid":false,"given":"Shunsuke","family":"Kidani","sequence":"first","affiliation":[{"name":"Human Information Science Japan Advanced Institute of Science and Technology  Nomi Japan"},{"name":"Faculty of Pharmaceutical Sciences Hokuriku University  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7051-5275","authenticated-orcid":false,"given":"Masatoshi","family":"Ukezono","sequence":"additional","affiliation":[{"name":"Department of Developmental Disorders National Institute of Mental Health, National Center of Neurology and Psychiatry  Kodaira Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8624-6922","authenticated-orcid":false,"given":"Yuji","family":"Takano","sequence":"additional","affiliation":[{"name":"The University of Human Environments  Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1471-9062","authenticated-orcid":false,"given":"Yasuhide","family":"Mitsumoto","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Hokuriku University  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00504983"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(85)90031-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(80)90067-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6773(74)90800-1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0071444"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244871"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00421183"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104928"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2013.05.003"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01272-X"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2008.01.014"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.03.001"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00291-1"}],"container-title":["Neuropsychopharmacology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.70161","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/npr2.70161","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.70161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:10:28Z","timestamp":1791274228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/npr2.70161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/npr2.70161"],"URL":"https:\/\/doi.org\/10.1002\/npr2.70161","archive":["Portico"],"relation":{},"ISSN":["2574-173X","2574-173X"],"issn-type":[{"value":"2574-173X","type":"print"},{"value":"2574-173X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]},"assertion":[{"value":"2026-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70161"}}