{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:52:06Z","timestamp":1791276726671,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Anxious distress is common in major depressive disorder (MDD), but real\u2010world data are limited on its burden and relationship to depressive symptom domains. This study examined the prevalence and symptom\u2010domain correlates of self\u2010reported anxious distress in MDD outpatients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study used routinely collected questionnaire and clinical data from Dokkyo Medical University Hospital. Depressive severity was assessed using the Japanese version of the Quick Inventory of Depressive Symptomatology (QIDS\u2010J). Anxious distress was assessed using five self\u2010rated items aligned with the Clinically Useful Depression Outcome Scale\u2010Anxious Distress (CUDOS\u2010A) and DSM\u20105 framework. Of 309 respondents, the primary analytic cohort comprised 206 participants with QIDS\u2010J total scores of 6 or higher and complete anxious\u2010distress item data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A lower anxious\u2010distress threshold (at least two items scored &gt;\u2009=\u20092) was met by 153 participants (74.3%), and a stringent threshold (at least two items scored &gt;\u2009=\u20093) by 85 (41.3%). QIDS\u2010J total score correlated with anxious\u2010distress burden (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.614 for &gt;\u2009=\u20092 count,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.669 for &gt;\u2009=\u20093 count, and\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.697 for summed score; all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In forced\u2010entry Poisson models, sad mood, negative self\u2010view, and psychomotor symptoms were associated with anxious\u2010distress burden. Post hoc decomposition suggested that this psychomotor association was driven mainly by psychomotor agitation rather than retardation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Self\u2010reported anxious distress was common among MDD outpatients and was closely associated with depressive severity and specific symptom domains, supporting further evaluation of anxious distress as a clinically relevant psychopathological dimension in MDD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.70165","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:25:11Z","timestamp":1788323111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Symptom\u2010Domain Correlates of Self\u2010Reported Anxious Distress in Outpatients With Major Depressive Disorder"],"prefix":"10.1002","volume":"46","author":[{"given":"Shinpei","family":"Oga","sequence":"first","affiliation":[{"name":"Department of Psychiatry Dokkyo Medical University  Mibu Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-664X","authenticated-orcid":false,"given":"Norio","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Dokkyo Medical University  Mibu Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9879-9492","authenticated-orcid":false,"given":"Yasushi","family":"Kawamata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Dokkyo Medical University  Mibu Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Asahi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Dokkyo Medical University  Mibu Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Dokkyo Medical University  Mibu Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakurako","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Dokkyo Medical University  Mibu Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Hiramatsu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Dokkyo Medical University  Mibu Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4414-3770","authenticated-orcid":false,"given":"Norio","family":"Yasui\u2010Furukori","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Dokkyo Medical University  Mibu Tochigi 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