{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:52:08Z","timestamp":1791276728102,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The course of depressive symptoms in mood disorders may be influenced by multiple clinical factors, making predictors of subsequent symptoms difficult to identify. This study examined whether affective temperaments are associated with depressive symptoms at one\u2010year follow\u2010up in middle\u2010aged and older patients with mood disorders without clinically relevant psychiatric comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This one\u2010year longitudinal observational study included 91 patients aged 40\u201375\u2009years with major depressive disorder (MDD) or bipolar disorder (BD) who were admitted to Hokkaido University Hospital for a recent major depressive episode, completed baseline assessments at discharge, and were followed for 1\u2009year after discharge. Patients with clinically relevant psychiatric comorbidities were excluded. Affective temperaments were assessed using the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire. Multiple linear regression analyses were performed to examine factors associated with the 17\u2010item Hamilton Depression Rating Scale (HAM\u2010D17) total score at one\u2010year follow\u2010up, and logistic regression analyses to examine factors associated with subthreshold or more severe depressive symptoms at one\u2010year follow\u2010up. Temperament\u2010by\u2010diagnosis interaction analyses were performed to examine whether these associations differed between MDD and BD. This study was approved by the ethics committee of Hokkaido University Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Depressive and cyclothymic temperaments were significantly associated with a higher HAM\u2010D17 total score at one\u2010year follow\u2010up after adjustment. Depressive temperament was also associated with non\u2010remission. A significant cyclothymic temperament\u2010by\u2010diagnosis interaction was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Depressive and cyclothymic temperaments may be clinically relevant for understanding residual depressive symptoms at one\u2010year follow\u2010up in middle\u2010aged and older patients with mood disorders without clinically relevant psychiatric comorbidities. The significant cyclothymic temperament\u2010by\u2010diagnosis interaction highlights the potential diagnosis\u2010specific relevance of affective temperament. Larger prospective studies are required to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.70170","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:30:44Z","timestamp":1789612244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Affective Temperaments With One\u2010Year Depressive Outcomes in Middle\u2010Aged and Older Patients With Mood Disorders Without Psychiatric Comorbidities"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9930-9179","authenticated-orcid":false,"given":"Takashi","family":"Ozaki","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Hokkaido University  Sapporo Hokkaido 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