{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:51:51Z","timestamp":1791276711538,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The p75 neurotrophin receptor ectodomain (p75NTR\u2010ECD) has been implicated in amyloid\u2010\u03b2\u2010related neurotoxicity, but cerebrospinal fluid (CSF) levels in late\u2010life depression (LLD) remain uncertain. We compared clinically diagnosed Alzheimer's disease (AD), LLD, and healthy controls (HC) and reassessed exploratory symptom and cognitive associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      CSF p75NTR\u2010ECD was measured in 50 participants (HC,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919; LLD,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919; AD,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912). The primary linear model adjusted for age, sex, and body mass index. Exploratory symptom and cognitive models additionally adjusted for diagnostic group; six\n                      <jats:italic>p<\/jats:italic>\n                      values underwent Benjamini\u2013Hochberg false discovery rate (FDR) correction. Plate and below\u2010calibrator sensitivity analyses were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CSF p75NTR\u2010ECD was higher in HC than in AD (B\u2009=\u2009131.2\u2009pg\/mL, 95% CI 42.8\u2013219.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and higher in LLD than in AD (B\u2009=\u2009154.6\u2009pg\/mL, 95% CI 68.9\u2013240.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); HC and LLD did not differ. No symptom or cognitive association remained significant after diagnostic\u2010group adjustment and FDR correction (all q\u2009\u2265\u20090.117). Plate adjustment did not materially change the primary contrasts. Excluding three concentrations below the lowest calibrator preserved the LLD\u2013AD contrast but attenuated the HC\u2013AD contrast.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CSF p75NTR\u2010ECD showed preliminary differences across clinically defined groups. Because the sample was small, the recruitment site was perfectly confounded with AD versus non\u2010AD status, and diagnoses were not uniformly biomarker\u2010confirmed, the findings do not establish causality, clinical diagnostic utility, or added value beyond established AD biomarkers and require independent multisite replication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/npr2.70171","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:14:31Z","timestamp":1789946071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebrospinal Fluid p75 Neurotrophin Receptor Ectodomain Levels Across Clinically Diagnosed Alzheimer's Disease, Late\u2010Life Depression, and Healthy Aging: A Preliminary Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2453-6080","authenticated-orcid":false,"given":"Wataru","family":"Omori","sequence":"first","affiliation":[{"name":"Department of Psychiatry NHO Kure Medical Center and Chugoku Cancer Center  Kure Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7245-9206","authenticated-orcid":false,"given":"Naoto","family":"Kajitani","sequence":"additional","affiliation":[{"name":"Division of Psychiatry and Neuroscience, Institute for Clinical Research NHO Kure Medical Center and Chugoku Cancer Center  Kure Hiroshima Japan"},{"name":"Department of Psychiatry and Neuroscience, Center for Metabolic Regulation of Healthy Aging, Faculty of Life Science Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9541-1635","authenticated-orcid":false,"given":"Mami","family":"Okada\u2010Tsuchioka","sequence":"additional","affiliation":[{"name":"Division of Psychiatry and Neuroscience, Institute for Clinical Research NHO Kure Medical Center and Chugoku Cancer Center  Kure Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9962-8444","authenticated-orcid":false,"given":"Minoru","family":"Takebayashi","sequence":"additional","affiliation":[{"name":"Division of Psychiatry and Neuroscience, Institute for Clinical Research NHO Kure Medical Center and Chugoku Cancer Center  Kure Hiroshima Japan"},{"name":"Department of Psychiatry and Neuroscience, Center for Metabolic Regulation of Healthy Aging, Faculty of Life Science Kumamoto University  Kumamoto 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