{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:52:48Z","timestamp":1791334368541,"version":"4.3.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropsychopharm Rep"],"published-print":{"date-parts":[[2026,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aims<\/jats:title>\n Although combining long\u2010acting injectable antipsychotics (LAIs) with psychosocial treatments for schizophrenia is important, psychiatrists' attitudes toward this approach remain underexplored. We investigated Japanese psychiatrists' perceptions of combining atypical LAIs with psychosocial interventions.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n An anonymous cross\u2010sectional web\u2010based survey was administered to 1038 mid\u2010career Japanese psychiatrists, of whom 69 provided complete responses. Participants' general attitude toward recommending atypical LAIs was dichotomized as positive or negative\/neutral, and they rated on a 4\u2010point scale the usefulness of combining atypical LAIs with five psychosocial interventions: (1) psychosocial treatment (e.g., psychoeducation), (2) day\/night care, (3) community care, (4) financial\/employment support, and (5) housing support.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Thirty\u2010nine respondents held a positive attitude toward recommending atypical LAIs, whereas 30 held a negative\/neutral attitude. A positive attitude was significantly associated with perceiving the combination as useful for psychosocial treatment (\n p<\/jats:italic>\n \u2009=\u20090.038), financial\/employment support (\n p<\/jats:italic>\n \u2009=\u20090.015), and housing support (\n p<\/jats:italic>\n \u2009=\u20090.041), but not for day\/night care (\n p<\/jats:italic>\n \u2009=\u20090.090) or community care (\n p<\/jats:italic>\n \u2009=\u20090.079). Free\u2010text rationales most commonly cited improved adherence and relapse prevention, enhanced illness insight, and synergistic effects as reasons for valuing the combination.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This exploratory study suggests that mid\u2010career Japanese psychiatrists, particularly those with a favorable attitude toward atypical LAIs, perceive the combination of LAIs with psychosocial support not merely as an adherence tool but as a synergistic strategy promoting broader functional recovery. Because respondents represent a small, predominantly male, self\u2010selected sample, the generalizability of the findings is limited.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/npr2.70173","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:19:36Z","timestamp":1791332376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perceived Utility of Combining Atypical Long\u2010Acting Injectable Antipsychotics With Psychosocial Interventions: An Exploratory Survey of Mid\u2010Career Psychiatrists in Japan"],"prefix":"10.1002","volume":"46","author":[{"given":"Shun","family":"Umetsu","sequence":"first","affiliation":[{"name":"Department of Psychiatry Toyohashi Mental Health Care Center, Matsuzaki Hospital Toyohashi Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4626-4218","authenticated-orcid":false,"given":"Yoshiyo","family":"Oguchi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Teikyo University Hospital, Mizonokuchi Kawasaki Kanagawa Japan"},{"name":"Department of Neuropsychiatry St. Marianna University School of Medicine Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8694-5643","authenticated-orcid":false,"given":"Nobumi","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Ashikaga Fujimidai Hospital Ashikaga Tochigi Japan"},{"name":"Department of Neuropsychiatry Kawasaki Municipal Tama Hospital Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"issue":"10","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"892","DOI":"10.4088\/JCP.v63n1007","article-title":"Prevalence of and Risk Factors for Medication Nonadherence in Patients With Schizophrenia: A Comprehensive Review of Recent Literature","volume":"63","author":"Lacro J. P.","year":"2002","journal-title":"Journal of Clinical Psychiatry"},{"issue":"3","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.4088\/JCP.v67n0317","article-title":"Medication Adherence and Long\u2010Term Functional Outcomes in the Treatment of Schizophrenia in Usual Care","volume":"67","author":"Ascher\u2010Svanum H.","year":"2006","journal-title":"Journal of Clinical Psychiatry"},{"issue":"3","key":"e_1_2_12_4_1","first-page":"1","article-title":"The Use of Long\u2010Acting Injectable Antipsychotics in Schizophrenia: Evaluating the Evidence","volume":"77","author":"Correll C. U.","year":"2016","journal-title":"Journal of Clinical Psychiatry"},{"issue":"4","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.9758\/cpn.2021.19.4.610","article-title":"Satisfaction Survey on Antipsychotic Formulations by Schizophrenia Patients in Japan","volume":"19","author":"Hatano M.","year":"2021","journal-title":"Clinical Psychopharmacology and Neuroscience"},{"key":"e_1_2_12_6_1","first-page":"797","article-title":"Large\u2010Scale Survey About Psychiatrists' Use, Knowledge and Attitudes to Depot Antipsychotics\u2014A Comparison Between Japanese and German Psychiatrist","volume":"15","author":"Fujii Y.","year":"2012","journal-title":"Japanese Journal of Clinical Psychopharmacology"},{"issue":"6","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1176\/appi.ps.56.6.735","article-title":"Recovery From Schizophrenia: A Concept in Search of Research","volume":"56","author":"Liberman R. P.","year":"2005","journal-title":"Psychiatric Services"},{"issue":"2","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/npr2.12435","article-title":"Barriers to Long\u2010Acting Injectable Atypical Antipsychotic Use in Japan: Insights From a Comparative Psychiatrist Survey","volume":"44","author":"Oguchi Y.","year":"2024","journal-title":"Neuropsychopharmacology Reports"},{"issue":"12","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.4088\/JCP.v67n1216","article-title":"Attitudes of Psychiatrists Toward Antipsychotic Depot Medication","volume":"67","author":"Heres S.","year":"2006","journal-title":"Journal of Clinical Psychiatry"},{"issue":"12","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1001\/archpsyc.1979.01780120013001","article-title":"Fluphenazine and Social Therapy in the Aftercare of Schizophrenic Patients. Relapse Analyses of a Two\u2010Year Controlled Study of Fluphenazine Decanoate and Fluphenazine Hydrochloride","volume":"36","author":"Hogarty G. E.","year":"1979","journal-title":"Archives of General Psychiatry"},{"issue":"1","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41537-023-00405-5","article-title":"Symptomatic, Functional and Quality\u2010Of\u2010Life Measures of Remission in 194 Outpatients With Schizophrenia Followed Naturalistically in a 6\u2010Month Non\u2010Interventional Study of Aripiprazole Once Monthly","volume":"9","author":"Correll C. U.","year":"2023","journal-title":"Schizophrenia"},{"issue":"6","key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/0004867419837358","article-title":"Long\u2010Acting Atypical Antipsychotics in Schizophrenia: A Systematic Review and Meta\u2010Analyses of Effects on Functional Outcome","volume":"53","author":"Olagunju A. T.","year":"2019","journal-title":"Australian and New Zealand Journal of Psychiatry"},{"issue":"5","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S2215-0366(21)00039-0","article-title":"Long\u2010Acting Injectable Versus Oral Antipsychotics for the Maintenance Treatment of Schizophrenia: A Systematic Review and Comparative Meta\u2010Analysis of Randomised, Cohort, and Pre\u2010Post Studies","volume":"8","author":"Kishimoto T.","year":"2021","journal-title":"Lancet Psychiatry"},{"issue":"2","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/13696998.2017.1379412","article-title":"Medication Adherence and Discontinuation of Long\u2010Acting Injectable Versus Oral Antipsychotics in Patients With Schizophrenia or Bipolar Disorder","volume":"21","author":"Greene M.","year":"2018","journal-title":"Journal of Medical Economics"},{"issue":"4","key":"e_1_2_12_15_1","first-page":"22","article-title":"A New Psychosocial Tool for Gaining Patient Understanding and Acceptance of Long\u2010Acting Injectable Antipsychotic Therapy","volume":"6","author":"Lasser R. A.","year":"2009","journal-title":"Psychiatry (Edgmont)"},{"issue":"3","key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/inm.13128","article-title":"Recovery\u2010Oriented Daily Care Practice for Community\u2010Based Mental Health Service Consumers in Japan: A Grounded Theory Approach","volume":"32","author":"Matoba K.","year":"2023","journal-title":"International Journal of Mental Health Nursing"}],"container-title":["Neuropsychopharmacology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.70173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/npr2.70173","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/npr2.70173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:19:39Z","timestamp":1791332379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/npr2.70173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1002\/npr2.70173"],"URL":"https:\/\/doi.org\/10.1002\/npr2.70173","archive":["Portico"],"relation":{},"ISSN":["2574-173X","2574-173X"],"issn-type":[{"value":"2574-173X","type":"print"},{"value":"2574-173X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"2025-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70173"}}