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On the other hand, regulatory problems persist with acutely toxic naturally occurring phycotoxins, which may accumulate unpredictably to toxic levels in seafood. However, a scarce supply of pure toxin often precludes the availability of acceptable toxicology studies describing their biological effects. An exception to this situation is domoic acid, a neurotoxic phycotoxin that produced numerous cases of severe human intoxication which demanded extensive toxicological study. This paper describes a series of ongoing studies initiated in the wake of the outbreak of domoic acid toxicity that occurred in 1987 in Eastern Canada. \u00a9 1994 wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/nt.2620020514","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T02:27:48Z","timestamp":1161138468000},"page":"334-339","source":"Crossref","is-referenced-by-count":42,"title":["Toxicology and seafood toxins: Domoic acid"],"prefix":"10.1002","volume":"2","author":[{"given":"Frank","family":"Iverson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Truelove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,30]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"461","volume-title":"Mycotoxins and Phycotoxins 1988,\u201d a collection of invited papers presented at the Seventh International IUPAC Symposium on Mycotoxins and Phycotoxins, Tokyo, Japan, 16\u201019 August 1988","author":"Aune T","year":"1988"},{"key":"e_1_2_1_3_1","unstructured":"BirdCK BoydRK BrewerD CraftCA de FreitasASW DyerEW EmbreeDJ FalkM RackMG FoxallRA GillisC GreenwellM HardstaffWR JamiesonWD LaycockMV LeblancP LewisNI McCullochAW McCullyGK McInerney\u2010NorthcottM McInnesAC McLachlanJL OdenseP O'NeilD PathakVP QuilliamMA RaganMA SetoPF SimPC TappenD ThibaultP WalterJA WrightJVC BackmanAM TaylorAR DewarD GilganM RichardDJA(1988):Identification of domoic acid as the toxic agent responsible for the P.E.I contaminated mussel incident. 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