{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T21:41:51Z","timestamp":1698442911288},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T00:00:00Z","timestamp":1148947200000},"content-version":"vor","delay-in-days":4167,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Natural Toxins"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Experiments were performed using an anaesthetised rat model to investigate the local inflammatory responses produced by intradermal injections of crude venom gland extracts from a number of Australian spiders, namely, <jats:italic>Phonognatha graeffei, Delena cancerides, Isopeda montana, Badumna insignis, Lampona cylindrata, Steatoda grossa, S. capensis<\/jats:italic> Hann. All of the venom gland extracts tested, with the exception of that from S. capensis, produced increases in vascular permeability consistent with acute inflammatory responses. The responses primarily involved the activation of 5\u2010HT receptors, since they were markedly reduced by the nonselective 5\u2010HT<jats:sub>1<\/jats:sub>\/5\u2010HT<jats:sub>2<\/jats:sub>\u2010receptor antagonist methiothepin. Some of the venoms caused liberation of endogenous mediators of inflammation, and some had components that acted directly on the vasculature to increase vascular permeability. Histamine appeared to have little if any role in the observed increases in vascular permeability following intradermal injection of the spider venoms. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/nt.2620030106","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T02:33:34Z","timestamp":1161138814000},"page":"21-25","source":"Crossref","is-referenced-by-count":2,"title":["Preliminary studies on the inflammatory actions of the venoms of some Australian spiders"],"prefix":"10.1002","volume":"3","author":[{"given":"Natalie V.","family":"Korszniak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Story","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,30]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"50","volume-title":"Muir's Textbook of Pathology","author":"Anderson JR","year":"1980"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(92)90045-7"},{"key":"e_1_2_1_4_1","first-page":"319","article-title":"A study of the necrotic actions of the venom of the wolf spider, Lycosa godeffroyi, on mouse skin","volume":"950","author":"Atkinson RK","year":"1990","journal-title":"Comp Biochem Physiol"},{"key":"e_1_2_1_5_1","first-page":"441","article-title":"Studies of the necrotic actions of the venoms of several Australian spiders","volume":"98","author":"Atkinson RK","year":"1991","journal-title":"Comp Biochem Physiol"},{"key":"e_1_2_1_6_1","first-page":"125","article-title":"The involvement of collagenase in the necrosis induced by the bites of some spiders","volume":"102","author":"Atkinson RK","year":"1992","journal-title":"Comp Biochem Physiol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1977.tb07499.x"},{"key":"e_1_2_1_8_1","unstructured":"EverittBJM(1974): \u201cPharmacological Investigations of Extracts from the Crown\u2010of\u2010Thorns Starfish (Acanthaster planci).\u201d PhD Thesis University of Melbourne pp192\u2013194."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(73)90005-6"},{"key":"e_1_2_1_10_1","first-page":"141","article-title":"A significant illness that was produced by the white\u2010tailed spider, Lampona cylindrata","volume":"151","author":"Gray M","year":"1989","journal-title":"Med J Austr"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1971.tb53203.x"},{"key":"e_1_2_1_12_1","first-page":"142","volume-title":"Recent Advances in Toxinology Research","author":"Korszniak NV","year":"1992"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1993.tb00585.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(94)90024-8"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13604.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(70)90009-7"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1980.tb07912.x"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-138903-1.50016-8"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00503817"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700750105"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1957.sp005795"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700860223"},{"key":"e_1_2_1_23_1","volume-title":"The Pharmacology of Inflammation","author":"Spector WG","year":"1968"},{"key":"e_1_2_1_24_1","first-page":"226","volume-title":"Australian Animal Toxins","author":"Sutherland SK","year":"1983"}],"container-title":["Natural Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnt.2620030106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nt.2620030106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T23:35:22Z","timestamp":1698276922000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nt.2620030106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1002\/nt.2620030106"],"URL":"https:\/\/doi.org\/10.1002\/nt.2620030106","archive":["Portico"],"relation":{},"ISSN":["1056-9014","1522-7189"],"issn-type":[{"value":"1056-9014","type":"print"},{"value":"1522-7189","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}