{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:29:16Z","timestamp":1768012156853,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T00:00:00Z","timestamp":1148947200000},"content-version":"vor","delay-in-days":4108,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Natural Toxins"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied if consumption of boiled fresh roots from sweet cassava varieties grown in Cuba resulted in exposure to cyanogenic glycosides and their final breakdown product, cyanide. When adult, nonsmoking subjects consumed 1\u20104 kg cassava over 2 days, their urinary levels of the main cyanide metabolite, thiocyanate, only increased from a mean \u00b1 SEM of 12 \u00b1 2 to 22 \u00b1 2 \u03bc.mol\/l, indicating a negligible cyanide exposure. Their mean urinary linamarin, the main cyanogenic glucoside in cassava, increased from 2 \u00b1 1 to 68 \u00b1 16 \u03bcmol\/l. In a second experiment 5 subjects consumed one meal of 0.5 kg boiled cassava that contained 105 \u03bc\u2010mol linamarin and 8 \u03bc.mol hydrogen cyanide (HCN). Quantitative urine collections prior to and after intake showed that 28% of linamarin was excreted during the following 24 hours, whereas a modest increase of urinary thiocyanate (SCN) only corresponded to the small amount of free HCN ingested. These results indicate that the dominant cyanogen in boiled cassava is glycosides that pass through the human body without causing cyanide exposure. It remains to be studied whether humans occasionally possess intestinal or tissue \u03b2\u2010glucosidases that can hydrolyse cyanogenic glycosides from cassava. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/nt.2620030210","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T02:37:56Z","timestamp":1161139076000},"page":"114-117","source":"Crossref","is-referenced-by-count":28,"title":["Fate in humans of dietary intake of cyanogenic glycosides from roots of sweet cassava consumed in Cuba"],"prefix":"10.1002","volume":"3","author":[{"given":"Teresa","family":"Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Lundquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Perez","family":"Cristi\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Rosling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,30]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"269","article-title":"Epidemic neuropathy","volume":"68","year":"1994","journal-title":"Weekly Epidemiol Rec"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/156482659201400201"},{"key":"e_1_2_1_4_1","first-page":"679","article-title":"Referenzwert f\u00fcr Kreatinin im Serum, ermittelt mit einer spezifischen enzymatischen Methode","volume":"17","author":"B\u00f6rner U","year":"1979","journal-title":"J Clin Chem Biochem"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470513712.ch11"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","unstructured":"CarlssonL MlingiN RonquistG RoslingH(1995):A specific and sensitive method for determination of linamarin in urine. 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