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Three major pathologic pathways underlying heart failure symptoms have been identified: fluid overload, inflammation, and oxidative stress. Prior research has demonstrated that three nutrients\u2010sodium, omega\u20103 fatty acids, and lycopene\u2010can alter these pathologic pathways. Therefore, the purposes of this study are to test the effects of a 6\u2010month nutrition intervention of dietary sodium reduction combined with supplementation of lycopene and omega\u20103 fatty acids on heart failure symptoms, health\u2010related quality of life, and time to heart failure rehospitalization or all\u2010cause death. The aims of this double blind\u2010placebo controlled study are (1) to determine the effects of a 6\u2010month nutrition intervention on symptom burden (edema, shortness of air, and fatigue) and health\u2010related quality of life at 3 and 6 months, and time to heart failure rehospitalization or all\u2010cause death over 12 months from baseline; (2) compare dietary sodium intake, inflammation, and markers of oxidative stress between the nutrition intervention group and a placebo group at 3 and 6 months; and (3) compare body weight, serum lycopene, and erythrocyte omega\u20103 index between the nutrition intervention group and a placebo group at 3 and 6 months. A total of 175 patients with advanced heart failure will be randomized to either the nutrition intervention or placebo group. \u00a9 2013 Wiley Periodicals, Inc. 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