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Although the association between depressive symptoms and certain nutrient deficiencies like iron, folate, or Vitamin B12 has been established, the specific relationship between low\u2010normal serum Vitamin B12 levels and depressive symptoms in pregnant women in the United States has not been studied closely. Using 2005\u20132006 National Health and Nutrition Examination Survey data, a secondary analysis was conducted to examine the association between low\u2010normal serum Vitamin B12 level and depression, as measured by a score of 10 or higher on the Patient Health Questionnaire\u20109, in pregnant women (<jats:italic>N<\/jats:italic>\u2009=\u2009174). In bivariate regression models, Vitamin B12 level, experiencing poverty, and pre\u2010pregnancy body mass index (BMI) were significant predictors of depression. In multivariate logistic regression models, pregnant women with low\u2010normal serum Vitamin B12 levels (<jats:italic>OR<\/jats:italic>\u2009=\u20093.82, 95% CI [1.10\u201313.31], <jats:italic>p\u2009&lt;\u2009<\/jats:italic>0.04) were 3.82 times more likely to experience depression, controlling for sociodemographic characteristics, pre\u2010pregnancy BMI, and the biomarkers hemoglobin and folate. Identifying and treating pregnant women with low\u2010normal Vitamin B12 levels may enhance prenatal depression management.<\/jats:p>","DOI":"10.1002\/nur.21951","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T14:23:45Z","timestamp":1558621425000},"page":"264-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Risk of depression in pregnant women with low\u2010normal serum Vitamin B12"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2749-8075","authenticated-orcid":false,"given":"Lora","family":"Peppard","sequence":"first","affiliation":[{"name":"George Mason University Fairfax Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeung Mi","family":"Oh","sequence":"additional","affiliation":[{"name":"George Mason University Fairfax Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Gallo","sequence":"additional","affiliation":[{"name":"George Mason University Fairfax Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee","family":"Milligan","sequence":"additional","affiliation":[{"name":"George Mason University Fairfax Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"e_1_2_8_1_2_1","unstructured":"Akkerman D. 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