{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:39:32Z","timestamp":1783057172371,"version":"3.54.6"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health Research Fund, co-financed by FEDER Fund","award":["PI15\/00897"],"award-info":[{"award-number":["PI15\/00897"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Research in Nursing &amp; Health"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a lack of consensus in the international scientific community with respect to the most suitable hydration strategies when attending nulliparous women during low\u2010risk births. This paper describes the protocol for a randomized controlled trial to compare two hydration strategies and their influence on maternal and neonatal morbidity. The study population consists of nulliparous women admitted to the obstetrics department of a University Hospital. The women are being randomized into two groups: the \u201coptimal hydration\u201d group, which will be guaranteed 300\u2009ml\/hr liquids (crystalloids and bottled mineral water) with a minimum diuresis of 35\u2009ml\/hr; and the \u201cvariability in hydration\u201d group, which will receive intravenous (alternating normal saline, Ringer's lactate solution, glucose, or Voluven\u00ae) and clear (bottled mineral water or isotonic drinks [Aquarius\u00ae]) liquids, without any established perfusion rate, and without established minimum diuresis. Outcomes for mothers include duration of labor, cesarean section, fever, and dehydration. Outcomes for newborns are respiratory distress, hypoglycemia, hyponatremia, jaundice, weight loss over 48\u2009hr, and breastfeeding difficulties. Analysis will be per\u2010protocol. Administering optimal hydration may improve health and safety for mothers and their newborn and reduce maternal and neonatal morbidity. The study is registered at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link>. The project received funding by the Ministry of Health of Spain and is approved by the Research Ethics Committee.<\/jats:p>","DOI":"10.1002\/nur.21998","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T01:53:22Z","timestamp":1575338002000},"page":"8-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of \u201coptimal hydration\u201d during labor: HYDRATA study protocol for a randomized clinical trial"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4170-0989","authenticated-orcid":false,"given":"Ana Bel\u00e9n","family":"Hern\u00e1ndez L\u00f3pez","sequence":"first","affiliation":[{"name":"Departamento de Obstetricia y Ginecolog\u00eda Hospital Universitario Puerta de Hierro\u2010Majadahonda Madrid Espa\u00f1a"},{"name":"Grupo de Investigaci\u00f3n en Enfermer\u00eda y Salud Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2010Segovia de Arana Madrid Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Muriel Miguel","sequence":"additional","affiliation":[{"name":"Departamento de Obstetricia y Ginecolog\u00eda Hospital Universitario Puerta de Hierro\u2010Majadahonda Madrid Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Fern\u00e1ndez\u2010Ca\u00f1adas Morillo","sequence":"additional","affiliation":[{"name":"Departamento de Obstetricia y Ginecolog\u00eda Hospital Universitario Puerta de Hierro\u2010Majadahonda Madrid Espa\u00f1a"},{"name":"Grupo de Investigaci\u00f3n en Enfermer\u00eda y Salud Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2010Segovia de Arana Madrid Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"L\u00f3pez Lapeyrere","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Enfermer\u00eda y Salud Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2010Segovia de Arana Madrid Espa\u00f1a"},{"name":"Centro de Salud Valle de la Oliva Madrid Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tirso","family":"P\u00e9rez Medina","sequence":"additional","affiliation":[{"name":"Departamento de Obstetricia y Ginecolog\u00eda Hospital Universitario Puerta de Hierro\u2010Majadahonda Madrid Espa\u00f1a"},{"name":"Escuela de medicina Universidad Autonoma de Madrid Madrid Espa\u00f1a"},{"name":"Grupo de Investigaci\u00f3n y Desarrollo de Nuevas T\u00e9cnicas Quir\u00fargicas en Ginecolog\u00eda Puerta de Hierro\u2010 Instituto de Investigaci\u00f3n Sanitaria Segovia Arana Madrid Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Salcedo Mari\u00f1a","sequence":"additional","affiliation":[{"name":"Departamento de Obstetricia y Ginecolog\u00eda Hospital Universitario Puerta de Hierro\u2010Majadahonda Madrid Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inocencia","family":"Fornet Ruiz","sequence":"additional","affiliation":[{"name":"Departamento de Obstetricia y Ginecolog\u00eda Hospital Universitario Puerta de Hierro\u2010Majadahonda Madrid Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Rubio Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Departamento de nefrolog\u00eda Hospital Universitario Puerta de Hierro\u2010Majadahonda Madrid Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4078-3540","authenticated-orcid":false,"given":"Montserrat","family":"Sol\u00eds Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Enfermer\u00eda y Salud Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro\u2010Segovia de Arana Madrid Espa\u00f1a"},{"name":"Unidad de Investigaci\u00f3n de Cuidados Hospital Universitario Puerta de Hierro\u2010Majadahonda Madrid Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"American Pregnancy Association(2013).Dehydration during pregnancy; about 2 screens. 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