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These women may benefit from easily accessible, nonpharmacologic, and inexpensive self\u2010management approaches, such as via internet and mobile\u2010based interventions, to prevent development of symptoms and\/or intervene with current symptoms. This paper summarizes the research protocol of a nationally\u2010funded large\u2010scale randomized controlled study to evaluate \u201cMamma Mia,\u201d a self\u2010guided program with 44 modules that women use throughout pregnancy to 6 months postpartum. The program contains a novel combination of components designed to enable women to enhance self\u2010efficacy, emotional self\u2010regulation, and perceived social support. The overall goal of this three\u2010arm longitudinal randomized controlled trial is to evaluate the effects and mechanisms of this self\u2010management approach in diverse women in the U.S. (<jats:italic>n<\/jats:italic>\u2009=\u20091950). Enrolled pregnant women will be randomly assigned to one of three groups: (1) \u201cMamma Mia\u201d alone, which is self\u2010guided; (2) \u201cMamma Mia Plus\u201d in which participants engage in the \u201cMamma Mia\u201d modules plus receive brief guided support from a registered nurse; or (3) usual prenatal\/postpartum care. The first specific aim is to evaluate effects by group on the primary outcome of interest, depressive symptoms, over time. The second aim is to evaluate effects by group on subjective well\u2010being, anxiety, and stress. Using a conceptual framework based upon Individual and Family Self\u2010Management Theory, the third aim is to evaluate possible mediators (self\u2010efficacy, emotion self\u2010regulation, perceived support) and possible moderators (e.g., race\/ethnicity, type of healthcare clinician) of this self\u2010management approach.<\/jats:p>","DOI":"10.1002\/nur.22092","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T19:56:46Z","timestamp":1608062206000},"page":"13-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Study protocol for a multisite randomized controlled trial of an internet and mobile\u2010based intervention for preventing and reducing perinatal depressive 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