{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T02:54:13Z","timestamp":1782356053041,"version":"3.54.5"},"reference-count":70,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R01NR017649"],"award-info":[{"award-number":["R01NR017649"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Research in Nursing &amp; Health"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hopelessness is associated with decreased physical activity (PA) and increased adverse events and death in patients with ischemic heart disease (IHD). Rates of PA in patients with IHD continue to be low in both hospital\u2010based cardiac rehabilitation and home settings. While researchers have investigated strategies to increase PA among patients with IHD, interventions to promote PA specifically in IHD patients who report hopelessness are lacking. We describe the protocol for a NIH\u2010funded randomized controlled trial designed to establish the effectiveness of a 6\u2010week intervention (<jats:italic>Heart Up!<\/jats:italic>) to promote increased PA in IHD patients who report hopelessness. Participants (<jats:italic>n<\/jats:italic>\u2009=\u2009225) are randomized to one of three groups: (1) motivational social support (MSS) from a nurse, (2) MSS from a nurse plus significant other support (SOS), or (3) attention control. Aims are to: (1) test the effectiveness of 6 weeks of MSS and MSS with SOS on increasing mean minutes per day of moderate to vigorous PA; (2) determine the effects of change in moderate to vigorous PA on hopelessness; and (3) determine if perceived social support and motivation (exercise self\u2010regulation) mediate the effects of the intervention on PA. A total of 69 participants have been enrolled to date. The protocol has been consistently and accurately used by research personnel. We address the protocol challenges presented by the COVID\u201019 pandemic and steps taken to maintain fidelity to the intervention. Findings from this study could transform care for IHD patients who report hopelessness by promoting self\u2010management of important PA goals that can contribute to better health outcomes.<\/jats:p>","DOI":"10.1002\/nur.22106","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T06:07:18Z","timestamp":1610690838000},"page":"279-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Heart up! RCT protocol to increase physical activity in cardiac patients who report hopelessness: Amended for the COVID\u201019 pandemic"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1135-5205","authenticated-orcid":false,"given":"Susan L.","family":"Dunn","sequence":"first","affiliation":[{"name":"Department of Biobehavioral Nursing Science, College of Nursing University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine B.","family":"Robbins","sequence":"additional","affiliation":[{"name":"College of Nursing Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan L.","family":"Tintle","sequence":"additional","affiliation":[{"name":"Department of Statistics Dordt University  Sioux Center Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen G.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science, College of Nursing University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf G.","family":"Bronas","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science, College of Nursing University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison P.","family":"Goodyke","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science, College of Nursing University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Luong","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science, College of Nursing University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Gutierrez\u2010Kapheim","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Nursing Science, College of Nursing University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holli A.","family":"DeVon","sequence":"additional","affiliation":[{"name":"School of Nursing University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.96.2.358"},{"key":"e_1_2_8_3_1","unstructured":"ActiGraph LLC. (2020).Actigraph research database.https:\/\/www.actigraphcorp.com\/research-database\/"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5539\/gjhs.v6n6p198"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.044"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0b013e3181d0c2ce"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.23.5.443"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000232"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.011"},{"key":"e_1_2_8_10_1","unstructured":"Centers for Disease Control and Prevention. (2020).Coronavirus disease 2019 (COVID\u201019).https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/need-extra-precautions\/groups-at-higher-risk.html"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6913e2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10945"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215513481046"},{"issue":"2","key":"e_1_2_8_15_1","first-page":"129","article-title":"Social relationships and health: Challenges for measurement and intervention","volume":"17","author":"Cohen S.","year":"2001","journal-title":"Advances in Mind\u2010Body Medicine"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b5631"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2013.11928898"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0012801"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.10.053"},{"issue":"3","key":"e_1_2_8_20_1","first-page":"153","article-title":"Hopelessness and depression in the early recovery period after hospitalization for acute coronary syndrome","volume":"26","author":"Dunn S. L.","year":"2006","journal-title":"Journal of cardiopulmonary rehabilitation and prevention"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0000000000000205"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/NNR.0000000000000474"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0193945913507634"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0017896918813610"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0b013e31819276ba"},{"key":"e_1_2_8_26_1","unstructured":"EuroQol Research Foundation. (2019).EQ\u20105D\u20105L User Guide 2019. Retrieved fromhttps:\/\/euroqol.org\/publications\/user-guides"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199805000-00021"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0000000000000059"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/GO.20.00118"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215510367970"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.983536"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2009.10.001"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9903-x"},{"key":"e_1_2_8_34_1","first-page":"65","article-title":"A simple sequential rejective multiple test procedure","volume":"6","author":"Holm S.","year":"1979","journal-title":"Scandinavian Journal of Statistics"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.2466\/13.15.PMS.111.5.608-624"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487312441728"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HCR.0000265034.39404.07"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e31815743ca"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-010-1403-0"},{"issue":"6","key":"e_1_2_8_40_1","article-title":"Promoting patient uptake and adherence in cardiac rehabilitation","author":"Karmali K. N.","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3928\/0048-5713-20020901-06"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000066322.21016.4A"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1521\/jscp.2005.24.6.811"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-020-0646-z"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0b013e3181be7a8f"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2011.02.007"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2015.10.007"},{"key":"e_1_2_8_49_1","volume-title":"Motivational interviewing: Helping people change","author":"Miller W. R.","year":"2013"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008483-200301000-00008"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0b013e31828c7812"},{"key":"e_1_2_8_52_1","unstructured":"National Institute of Nursing Research. (2014).Policy of the National Institute of Nursing Research for data and safety monitoring of extramural clinical trials. Retrieved fromhttps:\/\/www.ninr.nih.gov\/sites\/files\/docs\/NINR%20DSM%20Policy%202014%20FINAL.pdf"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1885-5857(06)60649-X"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0b013e31818c3b83"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2006.12.018"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCR.0b013e3182825531"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10111704"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304588"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0018416"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.55.1.68"},{"key":"e_1_2_8_61_1","first-page":"3","volume-title":"Handbook of self\u2010determination research","author":"Ryan R. M.","year":"2002"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2012.08.011"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318235eb4d"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.109.868588"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07061018"},{"key":"e_1_2_8_66_1","unstructured":"The Columbia Lighthouse Project. (2016).Guidelines For Triage Using the C\u2010SSRS. Retrieved fromhttps:\/\/cssrs.columbia.edu\/documents\/clinical-triage-guidelines-using-c-ssrs\/"},{"key":"e_1_2_8_67_1","unstructured":"U.S. Department of Health and Human Services. (2018). Physical activity guidelines for Americans (2nd ed.). Washington DC: U.S. Department of Health and Human Services. Retrieved fromhttps:\/\/health.gov\/sites\/default\/files\/2019-09\/Physical_Activity_Guidelines_2nd_edition.pdf"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-2-24"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.711"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.209767"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.058"}],"container-title":["Research in Nursing &amp; Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nur.22106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nur.22106","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nur.22106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T15:22:40Z","timestamp":1693668160000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nur.22106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"references-count":70,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/nur.22106"],"URL":"https:\/\/doi.org\/10.1002\/nur.22106","archive":["Portico"],"relation":{},"ISSN":["0160-6891","1098-240X"],"issn-type":[{"value":"0160-6891","type":"print"},{"value":"1098-240X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,11]]},"assertion":[{"value":"2020-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}