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Increased mechanistic understanding of the transition from acute to chronic low back and identification of predictive biomarkers could enhance the clinical assessment performed by healthcare providers and enable the development of targeted treatment to prevent and\/or better manage chronic low back pain. This study protocol was designed to identify the neurological and transcriptomic biomarkers predictive of chronic low back pain at low back pain onset. This is a prospective descriptive longitudinal inception cohort study that will follow 340 individuals with acute low back pain and 40 healthy controls over 2 years. To analyze the neurophysiological and transcriptomic biomarkers of low back pain, the protocol includes psychological and pain\u2010related survey data that will be collected beginning within 6 weeks of low back pain onset (baseline, 6, 12, 24, 52 weeks, and 2 years) and remotely at five additional time points (8, 10, 16, 20 weeks, and 18 months). Quantitative sensory testing and collection of blood samples for RNA sequencing will occur during the six in\u2010person visits. The study results will describe variations in the neurophysiological and transcriptomic profiles of healthy pain\u2010free controls and individuals with low back pain who either recover to pain\u2010free status or develop chronic low back pain.<\/jats:p>","DOI":"10.1002\/nur.22200","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T06:33:46Z","timestamp":1638772426000},"page":"11-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neurophysiological and transcriptomic predictors of chronic low back pain: Study protocol for a longitudinal inception cohort study"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-0144","authenticated-orcid":false,"given":"Angela","family":"Starkweather","sequence":"first","affiliation":[{"name":"School of Nursing, University of Connecticut Institute for Systems Genomics  Storrs Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9426-4522","authenticated-orcid":false,"given":"Kathryn","family":"Ward","sequence":"additional","affiliation":[{"name":"Pain and Translational Symptom Science University of Maryland School of Nursing  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bright","family":"Eze","sequence":"additional","affiliation":[{"name":"School of Nursing University of Connecticut School of Nursing  Storrs Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahleah","family":"Gavin","sequence":"additional","affiliation":[{"name":"Pain and Translational Symptom Science University of Maryland School of Nursing  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia L.","family":"Renn","sequence":"additional","affiliation":[{"name":"Pain and Translational Symptom Science University of Maryland School of Nursing  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan G.","family":"Dorsey","sequence":"additional","affiliation":[{"name":"Pain and Translational Symptom Science University of Maryland School of Nursing  Baltimore Maryland USA"},{"name":"Department of Anesthesiology, Department of Neural and Pain Sciences, School of Medicine, Professor School of Dentistry  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-10-r106"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000755"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2019.8876"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00438-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S40740"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-016-0994-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.10.009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7586"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"125","article-title":"Influence of body mass index on low back pain","volume":"23","author":"Chowdhury D.","year":"2014","journal-title":"Mymensingh Medical Journal"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.12.002"},{"key":"e_1_2_9_13_1","first-page":"293","volume-title":"Effect of cancer on quality of life","author":"Cleeland C. 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