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To date, research has focused on individual symptoms, which limits our understanding of how postpartum symptom clusters manifest and influence health. This secondary analysis used the Community and Child Health Network study data (<jats:italic>N<\/jats:italic>\u2009=\u20091784). No patient or public directly participated or contributed to the current analysis. Guided by the Symptom Management Theory, latent class analysis was performed to identify subgroups of postpartum women with different symptom experiences using observed variables at 6 months postpartum: anxiety (MINI\u2010anxiety), general stress (PSS\u201010), posttraumatic stress (PCL\u2010C), postpartum depression (EPDS), sleep disturbance (PSQI\u2010sleep disturbance), and sleep duration (PSQI\u2010sleep duration). Bivariate and multiple regression analyses were conducted to examine the association between subgroups and (a) individual characteristics and (b) long\u2010term depressive symptoms (CES\u2010D\u20109) and well\u2010being at 18 and\/or 24 months postpartum. Five subgroups were selected that had better\u2010fit indices, entropy, and interpretability. Subgroups were labeled as (1) Minimum overall, (2) Mild\u2010moderate overall, (3) Moderate\u2010high sleep symptoms, (4) High psychological symptoms, and (5) High overall. After adjusting for covariates, postpartum women in Subgroups 4 and 5 had higher CES\u2010D\u20109 scores at 18 and 24 months and lower well\u2010being scores at 24 months. More postpartum women in Subgroups 4 and 5 experienced a history of depression or unemployment. Clinicians should provide targeted interventions for postpartum women in high\u2010symptom subgroups.<\/jats:p>","DOI":"10.1002\/nur.22336","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T14:39:38Z","timestamp":1692887978000},"page":"485-501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identification of postpartum symptom subgroups and associated long\u2010term maternal depressive symptoms and well\u2010being"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0864-7867","authenticated-orcid":false,"given":"Jihye Kim","family":"Scroggins","sequence":"first","affiliation":[{"name":"School of Nursing Duke University Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Reuter\u2010Rice","sequence":"additional","affiliation":[{"name":"School of Nursing Duke University Durham North Carolina USA"},{"name":"School of Medicine Duke University Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-6719","authenticated-orcid":false,"given":"Debra","family":"Brandon","sequence":"additional","affiliation":[{"name":"School of Nursing Duke University Durham North Carolina USA"},{"name":"School of Medicine Duke University Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4844-4690","authenticated-orcid":false,"given":"Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Nursing Duke University Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-6402.2009.01506.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002927"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002633"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2008.09.020"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.4.531"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1891\/9780826159922.0008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jst084"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.6078"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4v"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01246098"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.112.1.155"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136404"},{"key":"e_1_2_10_14_1","first-page":"31","volume-title":"The social psychology of health: Claremont Symposium on Applied Social Psychology","author":"Cohen S.","year":"1988"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.15.1809"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.150.6.782"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1215\/03616878-2416247"},{"key":"e_1_2_10_18_1","unstructured":"Declercq E. 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