{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:52:28Z","timestamp":1787136748161,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Research in Nursing &amp; Health"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In utero<jats:italic>\/<\/jats:italic>peripartum antiretroviral therapy (IPA) exposure type was examined in relationship to mental health symptoms among 577 children with perinatally acquired HIV (CPHIV), children perinatally HIV exposed but uninfected (CHEU), and children HIV unexposed uninfected (CHUU). IPA exposure was categorized for CPHIV and CHEU as none, single\u2010dose nevirapine with or without zidovudine (sdNVP\u00b1AZT), sdNVP+AZT+lamivudine (3TC), or combination antiretroviral therapy (cART). Anxiety and depressive symptoms were reported at baseline, 6\u2010, and 12\u2010month follow\u2010up per behavioral assessment system for children. Multivariable linear mixed models were used to estimate differences (b) with 95% confidence intervals (95% CI) for IPA exposure types versus CHEU without IPA exposure. Depressive and anxiety symptoms were lower in CHUU relative to CHEU and CPHIV but did not differ between CPHIV and CHEU. CHEU with sdNVP\u00b1AZT exposure had greater anxiety (<jats:italic>b<\/jats:italic>\u2009=\u20090.51, 95% CI: [0.06, 0.96]) and depressive symptoms (<jats:italic>b<\/jats:italic>\u2009=\u20090.48, 95% CI: [0.07, 0.89]) than CHEU without IPA exposure. CHEU with sdNVP+AZT+3TC exposure had higher anxiety (<jats:italic>b<\/jats:italic>\u2009=\u20090.0.45, 95% CI: [0.03, 0.86]) and depressive symptoms (<jats:italic>b<\/jats:italic>\u2009=\u20090.72, 95% CI: [0.27, 1.17]) versus CHEU without IPA exposure. Depressive and anxiety symptoms were not different for CHEU and CPHIV exposed to cART (<jats:italic>b<\/jats:italic>\u2009=\u20090.12\u20130.60, 95% CI: [\u22120.41, 1.30]) and CHEU and CHUU (<jats:italic>b<\/jats:italic>\u2009=\u2009\u22120.04 to 0.08, 95% CI: [\u22120.24, 0.29]) without IPA exposure. Among CHEU, peripartum sdNVP\u00b1AZT and sdNVP+AZT+3TC but not cART compared to no IPA exposure was associated with clinically important elevations in anxiety and depressive symptoms. Monitoring of mental health trajectory of HIV\u2010affected children considering IPA is needed to inform mental health interventions. Patient Contribution: Caregivers and their dependents provided consent for participation and collaborated with study team to identify mutually convenient times for protocol implementation.<\/jats:p>","DOI":"10.1002\/nur.22359","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T09:40:33Z","timestamp":1701337233000},"page":"195-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["In utero\/peripartum antiretroviral therapy exposure and mental health outcomes at 8\u201318 years old: A longitudinal comparative study of children with perinatally acquired HIV, children perinatally HIV exposed but uninfected, and children unexposed uninfected from Uganda"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4664-1211","authenticated-orcid":false,"given":"Audrey","family":"Coventry","sequence":"first","affiliation":[{"name":"Department of Psychiatry 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