{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T07:58:09Z","timestamp":1785916689816,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The study was supported by the Danish Research Council"},{"name":"The Danish Council for Strategic Research (DanORC consortium)"},{"name":"The Danish Diabetic Association"},{"name":"Aarhus University"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Vascular growth is a prerequisite for adipose tissue (AT) development and expansion. Some AT cytokines and hormones have effects on vascular development, like vascular endothelial growth factor (VEGF\u2010A), angiopoietin (ANG\u20101), ANG\u20102 and angiopoietin\u2010like protein\u20104 (ANGPTL\u20104).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>In this study, the independent and combined effects of diet\u2010induced weight loss and exercise on AT gene expression and proteins levels of those angiogenic factors were investigated. Seventy\u2010nine obese males and females were randomized to: 1. Exercise\u2010only (EXO; 12\u2010weeks exercise without diet\u2010restriction), 2. Hypocaloric diet (DIO; 8\u2010weeks very low energy diet (VLED) + 4\u2010weeks weight maintenance diet) and 3. Hypocaloric diet and exercise (DEX; 8\u2010weeks VLED + 4\u2010weeks weight maintenance diet combined with exercise throughout the 12 weeks). Blood samples and fat biopsies were taken before and after the intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Weight loss was 3.5 kg in the EXO group and 12.3 kg in the DIO and DEX groups. VEGF\u2010A protein was non\u2010significantly reduced in the weight loss groups. ANG\u20101 protein levels were significantly reduced 22\u201025% after all three interventions (<jats:italic>P<\/jats:italic> &lt; 0.01). The ANG\u20101\/ANG\u20102 ratio was also decreased in all three groups (<jats:italic>P<\/jats:italic> &lt; 0.05) by 27\u201038%. ANGPTL\u20104 was increased in the EXO group (15%, <jats:italic>P<\/jats:italic> &lt; 0.05) and 9% (<jats:italic>P<\/jats:italic> &lt; 0.05) in the DIO group. VEGF\u2010A, ANG\u20101, and ANGPTL\u20104 were all expressed in human AT, but only ANGPTL\u20104 was influenced by the interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Our data show that serum VEGF\u2010A, ANG\u20101, ANG\u20102, and ANGPTL\u20104 levels are influenced by weight changes, indicating the involvement of these factors in the obese state. Moreover, it was found that weight loss generally was associated with a reduced angiogenic activity in the circulation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.20060","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T06:54:59Z","timestamp":1366181699000},"page":"454-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Effect of weight loss and exercise on angiogenic factors in the circulation and in adipose tissue in obese 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