{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T02:04:55Z","timestamp":1768615495924,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIDDK\/NIH","award":["U01-DK61230"],"award-info":[{"award-number":["U01-DK61230"]}]},{"name":"NIDDK\/NIH","award":["U01-DK61249"],"award-info":[{"award-number":["U01-DK61249"]}]},{"name":"NIDDK\/NIH","award":["U01-DK61231"],"award-info":[{"award-number":["U01-DK61231"]}]},{"name":"NIDDK\/NIH","award":["U01-DK61223"],"award-info":[{"award-number":["U01-DK61223"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The purpose of this study was to describe the prevalence of acanthosis nigricans (AN) and to quantify its association with dysglycemia in an ethnically diverse group of eighth\u2010grade students.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods:<\/jats:title><jats:p>Data were collected in 2003 from a cross\u2010sectional study of students from 12 middle schools in three US states. Sex, race\/ethnicity, and pubertal status were self\u2010reported. Anthropometric measures were recorded. Trained staff identified the presence and severity of AN by inspection of the back of the neck. Fasting and 2 h blood samples were analyzed for impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and high\u2010risk glycated hemoglobin (A1C), respectively, defined as \u2265100 mg\/dl, \u2265140 mg\/dl, and \u2265 5.7\u20106.4%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Overall, 25.0%, 58.2%, and 16.8% were Black, Hispanic, and White, respectively. AN was present among 406\/1,438 (28.2%) of students: 39% among Black, 30% among Hispanic, and 5.4% among White. IGT and high\u2010risk A1C were present among 2.1%, and 12.4%, respectively. In multivariate logistic modeling after adjusting for gender, family history of diabetes, BMI percentile, and pubertal staging, the presence (vs. absence) of AN was associated with a 59% increased likelihood of high\u2010risk A1C: (<jats:italic>P<\/jats:italic> = 0.04), twice the likelihood of IGT (<jats:italic>P<\/jats:italic> = 0.06), and 47% greater likelihood of IGT\/IFG combined (<jats:italic>P<\/jats:italic> &lt; 0.0001). Adjustment for insulin attenuated the ORs by 25\u201070%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>In a racially\/ethnically diverse sample of US adolescents, AN was common, occurring in 28% of the sample. AN was associated with a 50\u2010100% increased likelihood of dysglycemia even after consideration of established diabetes risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.20129","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T06:54:59Z","timestamp":1366181699000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The association between acanthosis nigricans and dysglycemia in an ethnically diverse group of eighth grade students"],"prefix":"10.1002","volume":"21","author":[{"given":"Lisa","family":"Rafalson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trang H.","family":"Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven 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