{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:50:15Z","timestamp":1780469415865,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T00:00:00Z","timestamp":1368403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>It is unclear why despite a comparable cardiometabolic risk profile, \u201cmetabolically benign\u201d overweight\/obese individuals show an elevated risk of cardiovascular disease compared to normal weight individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>In cross\u2010sectional analyses, we compared levels of ectopic fat (epicardial, pericardial, and hepatic fat) and adipokines (leptin, soluble leptin receptor, and high molecular weight [HMW] adiponectin) among metabolically benign (MBO) and at\u2010risk overweight\/obese (ARO), and metabolically benign normal weight (MBNW) women, screened for the Kronos Early Estrogen Prevention Study. We defined \u201cmetabolically benign\u201d with \u2264 1, and \u201cat\u2010risk\u201d with \u22652 components of the metabolic syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to MBO women, ARO women had significantly elevated odds of being in the top tertile of epicardial fat (OR: 1.76, 95% CI: 1.04\u20102.99), hepatic fat (OR: 1.90, 95% CI:1.12\u20103.24) and leptin (OR: 2.15, 95% CI: 1.23\u20103.76), and the bottom tertile of HMW\u2010adiponectin (OR: 2.90, 95% CI: 1.62\u20105.19). Compared to MBNW women, MBO women had significantly higher odds of being in the top tertile of epicardial fat (OR: 5.17, 95% CI: 3.22\u20108.29), pericardial fat (OR: 9.27, 95% CI: 5.52\u201015.56) and hepatic fat (OR: 2.72, 95% CI: 1.77\u20104.19) and the bottom tertile of HMW adiponectin levels (OR: 2.51, 95% CI: 1.60\u20103.94).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Levels of ectopic fat and the adverse adipokine profile increase on a continuum of BMI, suggesting that the metabolically benign phenotype may be a transient state.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.20200","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T12:59:59Z","timestamp":1368449999000},"page":"1726-1733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ectopic fat and adipokines in metabolically benign overweight\/obese women: The kronos early estrogen prevention study"],"prefix":"10.1002","volume":"21","author":[{"given":"Alexandra D.","family":"Ogorodnikova","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unab I.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Albert Einstein College of Medicine Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen P.","family":"McGinn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"Zeb","sequence":"additional","affiliation":[{"name":"Division of Cardiology Los Angeles Biomedical Research Institute at Harbor\u2010UCLA Torrance CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew 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Women's Hospital Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard N.","family":"Hodis","sequence":"additional","affiliation":[{"name":"Atherosclerosis Research Unit University of Southern California Keck School of Medicine Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Merriam","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System and Department of Medicine University of Washington School of Medicine Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelle I.","family":"Cedars","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences University of California at San Francisco San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh S.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, 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