{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:17:29Z","timestamp":1791227849737,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T00:00:00Z","timestamp":1368403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Fibroblast growth factor (FGF)\u201019 and FGF\u201021 are novel metabolic regulators that improve insulin resistance and obesity in rodents. The aim of the study was to assess the effects of laparoscopic sleeve gastrectomy (LSG) on serum concentrations of FGF\u201019 and FGF\u201021 along with circulating bile acids and other relevant hormonal and biochemical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>Seventeen females with obesity undergoing LSG and 15 lean healthy females were included into the study. Anthropometric and biochemical parameters, serum concentrations of FGF\u201019 and \u201021, insulin, adiponectin, leptin, C\u2010reactive protein, resistin, amylin (total), ghrelin (active), glucagon\u2010like peptide 1 (GLP\u20101, active), glucose\u2010dependent insulinotropic peptide (GIP, total), peptide YY (PYY, total), pancreatic polypeptide (PP), and bile acids, and mRNA expression of selected adipokines and inflammatory markers in bioptic samples of subcutaneous fat were assessed at baseline and 6, 12, and 24 months after LSG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LSG markedly decreased body weight, BMI, waist circumference, and insulin levels and improved systemic inflammation and lipid levels. FGF\u201019 concentrations increased and FGF\u201021 concentrations decreased after LSG along with increased adiponectin and decreased leptin, amylin, and ghrelin levels. GLP\u20101, GIP, PP, and circulating bile acids were not affected by LSG. PYY decreased significantly 24 months after surgery only. mRNA expression analysis in subcutaneous fat showed markedly reduced proinflammatory state.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that increased FGF\u201019 and decreased ghrelin concentrations could have partially contributed to the improvement of systemic inflammation and some metabolic parameters after LSG, while changes of FGF\u201021 are rather secondary because of weight loss.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.20208","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T13:08:48Z","timestamp":1368450528000},"page":"1335-1342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Laparoscopic sleeve gastrectomy differentially affects serum concentrations of FGF\u201019 and FGF\u201021 in morbidly obese subjects"],"prefix":"10.1002","volume":"21","author":[{"given":"D.","family":"Haluz\u00edkov\u00e1","sequence":"first","affiliation":[{"name":"3rd Department of Medicine 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic"},{"name":"Department of Sports Medicine 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Lacinov\u00e1","sequence":"additional","affiliation":[{"name":"3rd Department of Medicine 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kav\u00e1lkov\u00e1","sequence":"additional","affiliation":[{"name":"3rd Department of Medicine 1st Faculty of Medicine Charles University and General University Hospital Prague Czech 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