{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:20:56Z","timestamp":1791634856357,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":829,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1002\/oby.20336","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T12:32:54Z","timestamp":1360845174000},"page":"2322-2330","source":"Crossref","is-referenced-by-count":17,"title":["NF\u03baB as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status, and TNF\u03b1"],"prefix":"10.1002","volume":"21","author":[{"given":"Alison L.","family":"Harte","sequence":"first","affiliation":[{"name":"Division of Metabolic and Vascular Health; Warwick Medical School; University of Warwick; Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyanendra","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Division of Metabolic and Vascular Health; Warwick Medical School; University of Warwick; Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan K.","family":"Piya","sequence":"additional","affiliation":[{"name":"Division of Metabolic and Vascular Health; Warwick Medical School; University of Warwick; Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Barber","sequence":"additional","affiliation":[{"name":"Division of Metabolic and Vascular Health; Warwick Medical School; University of Warwick; Coventry UK"},{"name":"Human Metabolism Research Unit; WISDEM, UHCW; Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Clapham","sequence":"additional","affiliation":[{"name":"AstraZeneca R&D, CVGI Bioscience; Macclesfield Cheshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Al-Daghri","sequence":"additional","affiliation":[{"name":"Biomarkers Research Program, Biochemistry Department; College of Science; King Saud University; Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dara","family":"Al-Disi","sequence":"additional","affiliation":[{"name":"Division of Metabolic and Vascular Health; Warwick Medical School; University of Warwick; Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warunee","family":"Kumsaiyai","sequence":"additional","affiliation":[{"name":"Division of Metabolic and Vascular Health; Warwick Medical School; University of Warwick; Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ponnusamy","family":"Saravanan","sequence":"additional","affiliation":[{"name":"Division of Metabolic and Vascular Health; Warwick Medical School; University of Warwick; Coventry UK"},{"name":"Human Metabolism Research Unit; WISDEM, UHCW; Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Fowler","sequence":"additional","affiliation":[{"name":"Division of Metabolic and Vascular Health; Warwick Medical School; University of Warwick; Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"O'Hare","sequence":"additional","affiliation":[{"name":"Division of Metabolic and Vascular Health; Warwick Medical School; University of Warwick; Coventry UK"},{"name":"George Eliot Hospital; Nuneaton Warwickshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Metabolic and Vascular Health; Warwick Medical School; University of Warwick; Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G.","family":"McTernan","sequence":"additional","affiliation":[{"name":"Division of Metabolic and Vascular Health; Warwick Medical School; University of Warwick; Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,25]]},"reference":[{"key":"10.1002\/oby.20336-BIB0001|oby20336-cit-0001","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1007\/s00125-004-1553-x","article-title":"Monocytic expression of CD14 and CD18, circulating adhesion molecules and inflammatory markers in women with diabetes mellitus and impaired glucose tolerance","volume":"47","author":"Fogelstrand","year":"2004","journal-title":"Diabetologia"},{"key":"10.1002\/oby.20336-BIB0002|oby20336-cit-0002","doi-asserted-by":"crossref","first-page":"E740","DOI":"10.1152\/ajpendo.00302.2006","article-title":"Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes","volume":"292","author":"Creely","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1002\/oby.20336-BIB0003|oby20336-cit-0003","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1210\/jc.2006-1151","article-title":"The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes","volume":"92","author":"Kusminski","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20336-BIB0004|oby20336-cit-0004","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nm1185","article-title":"IKK-beta links inflammation to obesity-induced insulin resistance","volume":"11","author":"Arkan","year":"2005","journal-title":"Nat Med"},{"key":"10.1002\/oby.20336-BIB0005|oby20336-cit-0005","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/sj.ijo.0802701","article-title":"Inhibitor kappaB kinase is involved in the paracrine crosstalk between human fat and muscle cells","volume":"28","author":"Dietze","year":"2004","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1002\/oby.20336-BIB0006|oby20336-cit-0006","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S1097-2765(00)80262-2","article-title":"Female mice heterozygous for IKK gamma\/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti","volume":"5","author":"Makris","year":"2000","journal-title":"Mol Cell"},{"key":"10.1002\/oby.20336-BIB0007|oby20336-cit-0007","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1074\/jbc.275.12.9047","article-title":"The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)","volume":"275","author":"Aguirre","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1002\/oby.20336-BIB0008|oby20336-cit-0008","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature01137","article-title":"A central role for JNK in obesity and insulin resistance","volume":"420","author":"Hirosumi","year":"2002","journal-title":"Nature"},{"key":"10.1002\/oby.20336-BIB0009|oby20336-cit-0009","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1073\/pnas.0603509103","article-title":"Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance","volume":"103","author":"Tuncman","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/oby.20336-BIB0010|oby20336-cit-0010","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1074\/jbc.M101521200","article-title":"Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action","volume":"277","author":"Aguirre","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1002\/oby.20336-BIB0011|oby20336-cit-0011","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S1471-4892(03)00068-7","article-title":"JNK: A new therapeutic target for diabetes","volume":"3","author":"Bennett","year":"2003","journal-title":"Curr Opin Pharmacol."},{"key":"10.1002\/oby.20336-BIB0012|oby20336-cit-0012","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2337\/diab.45.7.881","article-title":"Effects of an engineered human anti-TNF alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM","volume":"45","author":"Ofei","year":"1996","journal-title":"Diabetes"},{"key":"10.1002\/oby.20336-BIB0013|oby20336-cit-0013","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.271.5249.665","article-title":"IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF alpha- and obesity-induced insulin resistance","volume":"2","author":"Hotamisligil","year":"1996","journal-title":"Science"},{"key":"10.1002\/oby.20336-BIB0014|oby20336-cit-0014","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1210\/jc.2007-2579","article-title":"Epicardial adipose tissue as a source of nuclear factor-kappaB and c-Jun N-terminal kinase mediated inflammation in patients with coronary artery disease","volume":"94","author":"Baker","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20336-BIB0015|oby20336-cit-0015","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1210\/jcem.87.5.8627","article-title":"Increased resistin gene and protein expression in human abdominal adipose tissue","volume":"87","author":"McTernan","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20336-BIB0016|oby20336-cit-0016","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1093\/nar\/29.4.e21","article-title":"Development of a sensitive multi-well colorimetric assay for active NF{{kappa}}B","volume":"29","author":"Renard","year":"2001","journal-title":"Nucl Acids Res"},{"key":"10.1002\/oby.20336-BIB0017|oby20336-cit-0017","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.2337\/db05-1494","article-title":"Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha in skeletal muscle cells involves MEK1\/2 and nuclear factor-kappaB activation","volume":"55","author":"Coll","year":"2006","journal-title":"Diabetes"},{"key":"10.1002\/oby.20336-BIB0018|oby20336-cit-0018","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1021\/jm0310986","article-title":"Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase","volume":"48","author":"Gaillard","year":"2005","journal-title":"J Med Chem"},{"key":"10.1002\/oby.20336-BIB0019|oby20336-cit-0019","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1038\/sj.ijo.0802501","article-title":"Inflammation and the IKK beta\/I kappa B\/NF-kappa B axis in obesity- and diet-induced insulin resistance","volume":"27","author":"Shoelson","year":"2003","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1002\/oby.20336-BIB0020|oby20336-cit-0020","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1476-9255-7-15","article-title":"Elevated endotoxin levels in non-alcoholic fatty liver disease","volume":"30","author":"Harte","year":"2010","journal-title":"J Inflamm"},{"key":"10.1002\/oby.20336-BIB0021|oby20336-cit-0021","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1475-2840-8-20","article-title":"Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies","volume":"15","author":"Al-Attas","year":"2009","journal-title":"Cardiovasc Diabetol"},{"key":"10.1002\/oby.20336-BIB0022|oby20336-cit-0022","first-page":"105","article-title":"Activation of nuclear factor-kappa B (NF-kappa B) in mononuclear cells (MNC)","volume":"196","author":"Aljada","year":"2002","journal-title":"Methods Mol Biol"},{"key":"10.1002\/oby.20336-BIB0023|oby20336-cit-0023","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1161\/01.CIR.0000142055.53122.FA","article-title":"Circulating mononuclear cells in the obese are in a proinflammatory state","volume":"110","author":"Ghanim","year":"2004","journal-title":"Circulation"},{"key":"10.1002\/oby.20336-BIB0024|oby20336-cit-0024","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nm1166","article-title":"Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB","volume":"11","author":"Cai","year":"2005","journal-title":"Nat Med"},{"key":"10.1002\/oby.20336-BIB0025|oby20336-cit-0025","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s00125-003-1313-3","article-title":"Modulation of insulin action","volume":"47","author":"Pirola","year":"2004","journal-title":"Diabetologia"},{"key":"10.1002\/oby.20336-BIB0026|oby20336-cit-0026","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.2337\/db08-1725","article-title":"c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-kappaB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals","volume":"58","author":"Sourris","year":"2009","journal-title":"Diabetes."},{"key":"10.1002\/oby.20336-BIB0027|oby20336-cit-0027","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1210\/jc.2009-0558","article-title":"c-Jun N-terminal kinase 1\/2 activation by tumor necrosis factor-alpha induces insulin resistance in human visceral but not subcutaneous adipocytes: reversal by liver X receptor agonists","volume":"94","author":"Fern\u00e1ndez-Veledo","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/oby.20336-BIB0028|oby20336-cit-0028","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.2337\/diabetes.51.5.1493","article-title":"Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro","volume":"51","author":"McTernan","year":"2002","journal-title":"Diabetes"},{"key":"10.1002\/oby.20336-BIB0029|oby20336-cit-0029","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1161\/01.CIR.0000161954.17870.5D","article-title":"Insulin-mediated upregulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by rosiglitazone","volume":"111","author":"Harte","year":"2005","journal-title":"Circulation"},{"key":"10.1002\/oby.20336-BIB0030|oby20336-cit-0030","doi-asserted-by":"crossref","first-page":"35361","DOI":"10.1074\/jbc.M504611200","article-title":"JNK and TNF\u03b1 mediated free fatty acid-induced insulin resistance in 3T3-L1 adipocytes","volume":"280","author":"Nguyen","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1002\/oby.20336-BIB0031|oby20336-cit-0031","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1002\/oby.20336-BIB0032|oby20336-cit-0032","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1002\/oby.20336-BIB0033|oby20336-cit-0033","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1365-3083.2011.02555.x","article-title":"MAPKs ERK and p38, but not JNK phosphorylation, modulate IL-6 and TNF-\u03b1 secretion following OK-432 in vitro stimulation of purified human monocytes","volume":"74","author":"Olsnes","year":"2011","journal-title":"Scand J Immunol"},{"key":"10.1002\/oby.20336-BIB0034|oby20336-cit-0034","doi-asserted-by":"crossref","first-page":"e20287","DOI":"10.1371\/journal.pone.0020287","article-title":"Visfatin Is Regulated by Rosiglitazone in Type 2 Diabetes Mellitus and Influenced by NF\u03baB and JNK in Human Abdominal Subcutaneous Adipocytes","volume":"6","author":"McGee","year":"2011","journal-title":"PLoS One"},{"key":"10.1002\/oby.20336-BIB0035|oby20336-cit-0035","doi-asserted-by":"crossref","first-page":"48115","DOI":"10.1074\/jbc.M209459200","article-title":"Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex","volume":"277","author":"Gao","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1002\/oby.20336-BIB0036|oby20336-cit-0036","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/35104568","article-title":"Inhibition of JNK activation through NF-kappaB target genes","volume":"414","author":"Tang","year":"2001","journal-title":"Nature"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Foby.20336","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/oby.20336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T15:45:00Z","timestamp":1625413500000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.20336"}},"subtitle":["NF\u03baB and JNK Expression in Human Abdominal Fat"],"short-title":[],"issued":{"date-parts":[[2013,5,25]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"URL":"https:\/\/doi.org\/10.1002\/oby.20336","archive":["Portico"],"relation":{},"ISSN":["1930-7381"],"issn-type":[{"value":"1930-7381","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5,25]]}}}