{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:28:44Z","timestamp":1761611324123},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,6,22]],"date-time":"2013-06-22T00:00:00Z","timestamp":1371859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The common marmoset as a model of early obesity was assessed. The hypotheses that juvenile marmosets with excess adipose tissue will display higher fasting glucose, decreased insulin sensitivity, and decreased ability to clear glucose from the blood stream were tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>Normal and obese (body fat &gt; 14%) common marmoset infants (<jats:italic>N<\/jats:italic> = 39) were followed up from birth until 1 year. Body fat was measured by quantitative magnetic resonance. Circulating glucose was measured by glucometer and insulin, adiponectin, and leptin by commercial assays. The quantitative insulin sensitivity check index (QUICKI; a measure of insulin sensitivity) was calculated for subjects with fasting glucose and insulin measures. Oral glucose tolerance tests (OGTTs) were conducted at 12 months on 35 subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 6 months, obese subjects already had significantly lower insulin sensitivity (mean QUICKI = 0.378 \u00b1 0.029 vs. 0.525 \u00b1 0.019, <jats:italic>N<\/jats:italic> = 11, <jats:italic>P<\/jats:italic> = 0.003). By 12 months, obese subjects also had higher fasting glucose (129.3 \u00b1 9.1 mg\/dL vs. 106.1 \u00b1 6.5 mg\/dL, <jats:italic>P<\/jats:italic> = 0.042), and circulating adiponectin tended to be lower (<jats:italic>P<\/jats:italic> = 0.057). Leptin was associated with percent body fat; however, birth weight also influenced circulating leptin. The OGTT results demonstrated that obese animals had a decreased ability to clear glucose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early\u2010onset obesity in marmosets results in impaired glucose homeostasis by 1 year.<\/jats:p><\/jats:sec>","DOI":"10.1002\/oby.20462","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T07:32:45Z","timestamp":1363764765000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Metabolic consequences of the early onset of obesity in common marmoset monkeys"],"prefix":"10.1002","volume":"21","author":[{"given":"Michael L.","family":"Power","sequence":"first","affiliation":[{"name":"Nutrition Laboratory, Conservation Ecology Center Smithsonian Conservation Biology Institute, National Zoological Park Washington District of Columbia USA"},{"name":"Research Department American College of Obstetricians and Gynecologists 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D.","family":"Tardif","sequence":"additional","affiliation":[{"name":"Barshop Institute for Longevity &amp; Aging Studies University of Texas Health Science Center San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29786"},{"key":"e_1_2_5_3_1","first-page":"769","article-title":"Obesity prevalence among low\u2010income, preschool\u2010aged children\u2014United States, 1998\u20102008","volume":"58","author":"Centers for Disease Control and 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