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Analysis of variance assessed cluster differences in weight loss maintenance at 15\u2010month follow\u2010up. Discriminant analysis identified baseline characteristics that best differentiated between clusters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants had baseline mean (SD) age of 55.0 (10.8) years and BMI of 31.9 (5.2) kg\/m<jats:sup>2<\/jats:sup>. Cluster analysis identified three short\u2010term weight loss patterns: modest (<jats:italic>n<\/jats:italic> = 15; 21%), moderate\u2010and\u2010steady (<jats:italic>n<\/jats:italic> = 43; 60%), and substantial\u2010and\u2010early (<jats:italic>n<\/jats:italic> = 14; 19%). Only participants with the latter two patterns achieved clinically significant (\u22655%) short\u2010term weight loss and maintained it at 15 months. On discriminant analysis, the modest cluster was most differentiated from other clusters by high friend encouragement for dietary change, high obesity\u2010related problems, and low physical well\u2010being. The moderate\u2010and\u2010steady cluster was differentiated by lower physical activity, family encouragement, and depression symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results provided insight into the heterogeneity of response to an effective lifestyle intervention by identifying short\u2010term weight loss patterns and their baseline predictors and relationship to 15\u2010month success. 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